CE44 - Biochimie du Vivant

Control of interorganelle membrane contact formation – CO-CON

Submission summary

Eukaryotic cells are compartmentalized in distinct organelles, each of them hosting specialized functions. They are not isolated from each other but physically and transiently connected, through the formation of membrane contact sites (MCS). The endoplasmic reticulum (ER) is the most connected organelle, owing to the presence along its surface of receptors of the VAMP-associated protein (VAP) family. These receptors VAP-A, VAP-B and the recently identified MOSPD2, by recognizing a short linear peptide motif called FFAT, are critical for the formation and the function of ER-organelle contact sites. Yet our knowledge on MCSs reaches its limit. We do not know how these contacts are regulated. The aim of this project is to unveil a new mechanism regulating the formation of MCS and establish the repertoire of constitutive and regulatable complexes bridging the ER with other organelles.

Project coordination

Catherine TOMASETTO (INSTITUT DE GENETIQUE ET DE BIOLOGIE MOLECULAIRE ET CELLULAIRE)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

IGBMC INSTITUT DE GENETIQUE ET DE BIOLOGIE MOLECULAIRE ET CELLULAIRE
IPMC Institut de pharmacologie moléculaire et cellulaire
IGBMC INSTITUT DE GENETIQUE ET DE BIOLOGIE MOLECULAIRE ET CELLULAIRE

Help of the ANR 447,778 euros
Beginning and duration of the scientific project: November 2019 - 48 Months

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