Hydrogen driven enantioselective assembly lines – H2-drive
The quest for new eco-compatible enantioselective paths requires the orthogonal catalytic activation of multiple building blocks. The solution to this challenge calls for the design of innovative multi-catalyzed processes that is the ambition of this proposal. The proposed strategy is based on hydrogen transfer-initiated reactions allowing access to complex enantioenriched structures of high synthetic value by an innovative OFF/ON assembly line. From an initial unactivated substrate (alcohol), metal-catalyzed dehydrogenation would provide the key activated carbonyl function triggering the subsequent enantioselective cascades. Final reaction by the hydrogen transfer catalyst would terminate the cascades affording the desired complex chiral structures.
Project coordination
Adrien QUINTARD ([CNRS - DR Alpes] Centre National de la Recherche Scientifique (CNRS) - Délégation Régionale Alpes)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partner
CNRS DCM UMR 5250 [CNRS - DR Alpes] Centre National de la Recherche Scientifique (CNRS) - Délégation Régionale Alpes
CNRS DR12_ISM2 Centre National de la Recherche Scientifique Délégation Provence et Corse_ISM2
Help of the ANR 207,640 euros
Beginning and duration of the scientific project:
September 2019
- 48 Months
