CE19 - Technologies pour la santé

Myeloperoxidases : formulation of antimicrobial materials to prevent nosocomial infections – MicrobicidalEnzyme

Submission summary

Mono- or multi-species biofilms give rise to a wide range of chronic infections extremely difficult to eradicate and negatively impacting the quality of life of patients and increasing mortality. It is therefore highly desirable to generate on the top surface of medical devices a broad spectrum of antimicrobial activity, without inducing the development of any microorganism resistance. Myeloperoxidase (MPO) catalyzes the formation of hypochloric acid from hydrogen peroxide and chloride which confers to the common household bleach its antimicrobial activity. In MicrobicidalEnzyme project, we aim at producing recombinant MPO enzymes from yeast or bacteria at lower costs and higher yields than the currently available human one. In a second step, taking advantage of the antimicrobial properties of MPOs, we will develop silicone model surfaces coated with microbicidal MPO and then assess their antimicrobial efficiency in the presence of a large panel of infectious agents. In a last step, as a proof of concept the current approach will be transferred to commercial available urinary catheters to help fighting the formation of biofilms. To reach these multiple objectives, the MicrobicidalEnzyme project gathers two partners, the Centre de Recherche Paul Pascal and the Etablissement Français du Sang, and three teams with strong know-how respectively in biochemistry, enzymes and elaboration of functional materials (CRPP) and quality control for sterility tests and bioburden testing on surfaces (EFS). The Microbicidalenzyme project will likely impact and bring new scientific and technological advances in different communities ranging from medicine, pharmacology, enzymology, to biotechnology through advanced materials for biomedical applications.

Project coordination

Claire STINES-CHAUMEIL (CENTRE DE RECHERCHE PAUL PASCAL)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

C.R.P.P CENTRE DE RECHERCHE PAUL PASCAL
EFS NVAQ Etablissement Français du Sang Nouvelle Aquitaine

Help of the ANR 437,645 euros
Beginning and duration of the scientific project: - 48 Months

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