DS0305 -

Hyperelastic and absorbable structured biomaterials for the reconstruction of soft tissues – BioScaff

Submission summary

This multidisciplinary project focuses on the development of new scaffolds dedicated to the regeneration of soft tissues. In order to optimize the development of new implantable medical devices, the objective of this project is to promote and validate a methodological approach to forecast the evolution of the mechanical properties of the biocomposite "scaffold/growing cells" during the antagonistic effects of the biodegradation of the scaffold and cell colonization. For this purpose, new biocompatible and biodegradable block copolymers having hyper elastic behavior close to that of soft
tissues will be synthesized. These materials will be processed by electrospinning to produce biomimetic structures favoring the cellular growth. The mechanical properties of the scaffolds will be characterized at various stages of degradation in the presence of growing cells. Simulation methods, from the cellular scale up to that of the scaffolds will integrate the experimental results to characterize and finally forecast mechanical behavior of scaffolds according to these
intrinsic properties.

Project coordination

Frédéric Bossard (Laboratoire Rhéologie et Procédés)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


IBMM-BA Institut des Biomolécules Max Mousseron - Biopolymères Artificiels
LRP Laboratoire Rhéologie et Procédés
TIMC-IMAG Laboratoire Technique de l'Ingénierie Médicale et de la Complexité – Informatique, Mathématiques et Applications de Grenoble

Help of the ANR 492,674 euros
Beginning and duration of the scientific project: January 2017 - 36 Months

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