BLANC - Blanc

Nanostructured polymers as drug carriers for cartilage repair and engineering – PARTICART

Submission summary

This project which associates polymer chemists/physico-chemists, biologists and manufacturers concerns design and synthesis of new nanoparticulate polymeric carriers, injectable in a cartilage defect and allowing a targeted drug delivery in chondrocytes or synoviocytes, for treatment of articular diseases. The present study has the following goals: - to synthesize, in liquid or supercritical phase, of nanosized particle systems, based on functional, biocompatible and (bio)degradable polymers - to evidence the targeting of the nanospheres to cartilage cells, using particles labelled with fluorescent probes - to encapsulate active molecules (e.g. corticosteroids, chondroprotecting glycosaminoglycans) to thoroughly assess the biological properties. In fact, the mid term goal of this research program is to develop new formulations with various advantages: a targeted sustained release of active agents in the articular joint, the decrease of undesired side-effects due to high concentrations of anti-inflammatory/analgesic drugs, so as to limit the number of injections... The general aim is to draw, from the results of the biological assessment, relevant parameters (particle composition, morphology and size, nature of active molecules...) to treat articular diseases in order to be able to fit the nanosystem to be used, to each pathology. At longer term, one could also reconsider the use of certain new molecules, so far disregarded owing to their strong undesirable side-effects or their lack of tissular selectivity. ...

Project coordination

Michèle LEONARD (Organisme de recherche)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

Help of the ANR 380,000 euros
Beginning and duration of the scientific project: - 36 Months

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