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Control of the Expression of the “AFL” REgulatory network and Seed development – CERES
Le développement et la maturation des graines sont contrôlés par quelques facteurs clefs de régulation de la transcription. La régulation de l’expression de ces facteurs est mal connue, en particulier sa composante chromatinienne. Ce projet vise à comprendre les mécanismes impliqués.
Role of ubiquitination in the regulation of intracellular MHC class I traffic and in cross-presentation – MARCHxIRAP
Role of ubiquitination in the regulation of intracellular MHC class I traffic and in cross-presentation
Combining mass spectrometry and functional analyses for a comprehensive study of the phosphorylation of the Cav3.2 T-type calcium channel – Phospho-Cav
Identifier de nouvelles stratégies thérapeutiques pour traiter l’épilepsie, la douleur, dépend de notre capacité à caractériser de nouvelles cibles. Les canaux calciques de type T en font partie et le challenge relevé par ce projet est d’identifier l’impact de la phosphorylation sur les propriétés fonctionnelles des canaux calciques de type T
Babylonian Archives (20th-17th century B.C.). Phase 2 – ARCHIBAB-2
Babylonian archives (20th-17th centuries B.C.)
Evolution of nuclear hormone receptors ligand binding abilities : the contribution of the amphioxus model – AmphiNR
Understanding how the affinity of a nuclear receptor for its ligand was modified during evolution is a prerequisite to explore Nuclear Receptors (NR) pharmacology. NR modulators already represent 10% of all medicines being sold at pharmaceutical market these days, so they are particularly interesting as therapeutic targets.
Bacteria with Multiple Chromosomes : Interplay between genome architecture and cell physiology – BMC
Notre projet vise à déterminer les avantages sélectifs conférés par l’organisation génomique en multiple chromosomes chez les Vibrio. Ce projet permettra d’établir quels mécanismes sont à la source des différences d’organisation et de contenu en gènes dans les deux chromosomes des espèces du genre Vibrio
Chromatin dynamics during T lymphocyte activation: role of HP1 – chromaTin
Study of the role of HP1-silencing pathway in the development of different T helper (TH) lineages. Functional consequences of the impaired off-lineage gene silencing on TH phenotypes
Impact of fatty acids on infection by low GC% Gram positive pathogens – FattyBact
Fatty acids are commonly present in foods and animal blood and tissues, and can easily assimilate in the membranes of essentially all types of cells. We are examining the impact of fatty acid assimilation on opportunist pathogen bacteria, especially how they might change the pathogen life style and sensitivities to antibiotics.
Interactive Atlas of the Ancient Adriatic – AdriAtlas
This project offers a computerized Atlas of ancient Adriatic, made up of a database connected to an interactive map, available for online consultation. This atlas will be consistent with the current status of knowledge on the Adriatic area, from the end of the Bronze Age (XIth c. B.C.) up to late Antiquity (VIIIth c. A.D.).