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RNA therapy using antisens oligonucleotides targeting replication and transcription of SARS-CoV-2 – SARS-CoV2 ASO
project is to validate the best ASO firstly by in vitro experiments on infected Vero E6 cultures, and secondly [...] secondly to test the best oligonucleotides antisense in vivo on infected animal model to perform a preclinical
Inflammatory Vesseloid ON chip – IVEON
been extremely well studied in vitro and in vivo. However, 2D in vitro models do not capture the spatial [...] organization of vessels and the complexity of an in vivo environment. Thus, the challenge resides in the
Development and evaluation of multiphasic, biomimetic substitutes of the dura mater – DuraLayer
objective is here to develop, thanks to an extensive in vitro cell characterization step, specific phases promoting [...] differentiation and functionality (WP3). Such an in vitro exhaustive cellular analysis will not only highlight [...] but will also strengthen our knowledge of the in vitro behaviour of dural cells, still limited nowadays
Modulation of myofibers integrity and function in health and disease – Atrorescue
we will use in vitro cellular assays (cultured myotubes and mature myofibers) and in vivo mouse models [...] control of the ER, SR, T-tubules and ECC, in vitro and in vivo. Thus, ATRORESCUE will improve our understanding [...] as a strategy to rescue CNM related phenotypes in vivo may pave the way to treat other neuromuscular diseases
Adipose tissue-derived progenitors are essential protagonists of Skeletal Muscle Regeneration – ARMURE
realistic project based on a combination of in vitro and ex vivo experiments lying on both mastered and cutting [...] muscle stem cell function in vitro as a prelude start to functional in vivo approaches and then the c [...] different animal models. With these integrated in vivo approaches we expect to show that the transient
KREMEN2, an inhibitor of NF-kB-mediated auto-inflammation involved in human genetic disease – KREM-AIF
molecular, cellular and therapeutic using in-vitro, ex-vivo and in-vivo approaches. Our proposal is : i) [...] target genes, cell specificities). iii) To study in vivo KREMEN2 functions and screen for drugs targeting
Muscle release Extracellular vesicles in the context of Insulin-resistance associated with Diabetes (MEXID) – MEXID
to the extrapolation of the results obtained in vitro due to the lack of animal models making it possible [...] to follow their secretion / fate / integration in vivo. This project proposes to use zebrafish to bridge
The microtubule cytoskeleton network in thyroid development and physiology and platelet functions – MITHYPLA
platelet function in already established in vivo and in vitro models.
Novel bioprinting approaches for the creation of advanced pancreatic cancer initiation models – BioPrint_PaCiniMo
and progressive disease, for which advanced in vitro models are needed to enable decrypting of its initiation [...] control over the model design and replicate the in vivo precancerous niche. These tools can then be applied
Hematopoietic stem cells metabolism during expansion – HSC_Met_Expansion
- Modify the metabolism of fetal HSCs, in vitro and in vivo to validate its regulatory role in expansion