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Targeting host-parasite interactions through the inhibition of excreted Leishmania casein kinase 1 – TEXLEISH
assessment of its efficacy, toxicity, in vitro bioavailability, in vivo efficiency on animal models and the [...] kinase-based drug discovery, parasite biology and in vivo testing to optimize CTN1122, a potent antileishmanial
Prevention and gene therapy of viral encephalitis using specific interferon-stimulated genes – ISG-therapy
the best hits will be tested in mice in vitro and in vivo using AAV gene transfer to target ISG expression [...] implement this strategy in animal models. First, an in vivo overexpression screen of ~60 ISGs will be conducted [...] conducted in zebrafish. This large cell type-specific in vivo screen will be made possible thanks to a novel
Photoswitchable Nanoparticles for High-Contrast Photoacoustic Microscopy to Image Inflammation in Microvasculature – AZOTICS
capability will be validated through an in vitro, in cellulo and in vivo continuum of studies involving macrophage [...] (PA) stimulates novel research areas in biology. In vivo tracking of immune cells, signaling inflammation [...] propose innovative photoacoustic systems for in vivo imaging.
All-in-one 3D cell-based hollow liver capsules for drug screening assays: a comprehensive engineering, functional and molecular investigation – REVIL
robust protocols to recapitulate in vitro the proliferative in vivo capability of PHHs encountered during [...] need for the design and development of reliable vitro human hepatic models that may be eligible for the [...] the environmental cues received by hepatocytes in vivo, including the physical interactions between PHHs
Importance of novel myeloperoxidases-derived oxidants during neutrophil-Salmonella interactions – NeutrOX
hydroperoxide (UA-OOH) has been only obtained in vitro. N-ChT was shown to be generated by the reaction [...] we propose to decipher for the first time the in vivo antimicrobial activity of these candidates MPO- [...] Salmonella. Second, we will characterize the in vitro antimicrobial activities of N-ChT and UA-OOH against
COVID-19 and platelet derived DNA in acute respiratory distress syndrome (ARDS) – PlatdeDNA
The recent and persistent COVID pandemic is adding to the high death toll rate largely due to virus infection induced severe acute respiratory distress syndrome (ARDS) with strong lung inflammation, disruption of the alveolar barrier, acute lung edema, sudden respiratory failure and pulmonary thrombosis. Platelets trigger the thrombotic process and amplify inflammation through interaction with granulocytes generating extracellular dsDNA release, neutrophil extracellular traps, the release of bioactive substances along with the generation of procoagulant platelets in addition to canonical aggregation.
Validation of a bioaccessibility method for endocrine disruptors in indoor dust – BIOACID
validation, using in vivo tests on pigs, of an already existing, simplified in vitro method, taking into [...] inal tract and available for absorption. An in vitro method for measuring the bioaccessibility of EDCs
First pre-clinical validation of fluorinated ligands for the 18F TEP diagnosis of synucleinopathies – Syn4Diag
need to evaluate potential tracers using in vitro and in vivo models which faithfully reflect the pathological [...] emission tomography (PET) is a unique tool for the in vivo exploration of neurodegenerative diseases characterized [...] selectivity for a-syn, ii) the screening of in vitro binding properties of new compounds through competition
Modulation of Neurotransmission by Therapeutic Ultrasound – MONTUS
as well as in vivo studies on rat models. Experimental setups for in vitro and ex vivo studies will consist [...] MONTUS project will include a variety of in vitro and ex vivo experimentation on neuronal cell cultures [...] by intracellular calcium dynamics. Likewise, in vivo studies aimed at characterizing the efficacy and
Gut microbiota-derived metabolites: natural products to promote epithelial barrier maturation at the suckling-to-weaning transition – MetaboWean
early life. A combination of in vivo (suckling rabbit model) and in vitro (rabbit intestinal organoids) [...] bring the proof of concept that they can be used in vivo to promote epithelial maturation at the sucklin