Validation of a bioaccessibility method for endocrine disruptors in indoor dust – BIOACID
People spend nearly 90% of their time indoors where they are exposed to many pollutants. Among these pollutants, semi-volatile organic compounds (SVOCs) are of particular concern as most of them are suspected to be endocrine disruptors (EDCs) with adverse health effects such as reprotoxic, neurotoxic and carcinogenic effects. Scientific literature shows that indoor dust ingestion is a significant route of exposure to some EDCs. Children, due to frequent hand-to-mouth contact, are particularly affected, not only at home but also at school. For a better evaluation of the associated health risks, a better knowledge of the real exposure to these pollutants is needed, starting with a better understanding of the absorbed dose. To this end, it is necessary to assess the oral bioaccessibility of EDCs, defined as the fraction of pollutant released into the gastrointestinal tract and available for absorption. An in vitro method for measuring the bioaccessibility of EDCs in dust could be used, but up to now, no method has been validated.
In this context, this project first proposes the validation, using in vivo tests on pigs, of an already existing, simplified in vitro method, taking into account the dynamics of digestion, and then its deployment on measurement campaigns on settled dust already available from schools and dwellings. A method for modeling the bioaccessible fraction will also be developed as a less expensive alternative for specific pollutants adsorbed only on the surface of the dust. This project will produce initial bioaccessible concentration results for phthalates, organophosphates and pyrethroids in indoor dust and assess the impact of oral bioaccessibility in terms of accuracy of risk assessment.
Madame Barbara LE BOT (Laboratoire d'Etude et de Recherche en Environnement et Santé)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
LERES Laboratoire d'Etude et de Recherche en Environnement et Santé
URAFPA UNITÉ DE RECHERCHES ANIMAL ET FONCTIONNALITÉS DES PRODUITS ANIMAUX
Help of the ANR 533,467 euros
Beginning and duration of the scientific project: August 2022 - 48 Months