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3D integrated multifunctional MRI sensors based on Molded Interconnect Device technology in tissue engineering regenerative medicine – ESTIMATE
In the last decades, the progress in the field of tissue engineering for regenerative medicine (TERM) has been tremendous. However, there is still no effective 3D method to evaluate non-invasively in vitro and in vivo engineered tissues. Therefore, the main objective of ESTIMATE is to democratize multiparametric MRI for the characterization of engineered tissues from the synthesis to the implantation stage.
Topical dermal delivery of anti-inflammatory drugs with catanionic vesicles for the treatment of psoriasis – TANDANSS
Currently, the topical administration of drugs is the first line and the most practical medication method for psoriasis patients. However, these treatments are replaced, for the most severe forms of the disease, with systemic administration of synthetic drugs with severe side effects. There is undoubtedly an unmet medical and societal need for the development of a topical administration route of new drugs that could provide sustainable remissions and life quality improvements for patients.
Axonal transport and neuronal maturation: consequences for synaptic function and neuronal connections in health and Huntington’s disease. – AXYON
connectivity in vivo using a combination of genetic and in utero manipulations in mouse, and in vivo imaging [...] and dendritic transport in health and disease in vitro. While HTT-regulated transport may contribute to [...] t of synapses. We will use state of the art in vitro microfluidic devices recapitulating physiological
Emerging mycotoxins: a new risk for Human and animals? – EmergingMyco
Mycotoxins produced by certain molds contaminate more than 70% of the world's cereals and represent a public health problem. The main toxins of Fusarium are regulated in Europe in food and feed. However, Fusarium produce other mycotoxins that are known as «emerging« mycotoxins because they are poorly characterized or recently identified. This project aims to determine their occurrence in French cereals and their toxicity.
Hepatic sphingolipids in NAFLD: from liver biosynthesis to metabolic consequences – SONIC
test these hypotheses, we will conduct in vitro and in vivo studies in animals and humans with three [...] pharmacological agent to inhibit lipogenesis in vitro. In vivo we will use an adenovirus expressing a dominant [...] inflammation and the underlying mechanisms. In in vitro studies on primary rodent and human hepatocytes
Oral exposure and gut-targeted toxicity of PFOA and its precursor 8:2 FTOH under chronic stress: when high-resolution chemical imaging bridges food toxicology – FLUO-GUT
Les substances perfluoroalkylées (PFAS) sont utilisés depuis plus de 60 ans dans un grand nombre de produits industriels. Le PFOA, l'un des représentants majeurs des PFAS, se caractérise par une forte persistance dans l'environnement malgré les restrictions d'utilisation, une présence ubiquitaire et une toxicité avérée. Le projet FLUO-GUT vise à une meilleure compréhension de son devenir après ingestion et des perturbations induites sur la sphère digestive et sur l’axe intestin/foie.
Evolution and function of plant NO-Synthases – ALGAE-NOS
studies, structural characterization, and in vitro/in vivo functional investigations: In silico: we will [...] activity for distinct physiological settings. In vivo: in vivo activity and role of plant NOSs will be investigated [...] critical role in NOS function or structure. In vitro: the structure of the catalytic site of model NOSs
Joint research laboratory for evaluating the potential of algae in anti-infectious health in livestock production – ALGAHEALTH
s. The UMR-ISP has developed several in vitro and in vivo tools and analysis models recognized by the [...] of bioactive ingredients (AMADEITE), - The in vitro screening of these bioactive compounds by growth
Dialogue(s) for fertility: deciphering spermatozoa-oviduct interactions and their implications for artificial insemination in dairy cattle – DIALOG
oviductal secretome in vivo; 2) translate the in vivo oviductal milieu into a refined in vitro model to faithfully
Syncytins for genome engineering in B cells – SYN-B
New genome-editing technologies for reprogramming the specificity or properties of antibodies in B lymphocytes