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Validation of a bioaccessibility method for endocrine disruptors in indoor dust – BIOACID
validation, using in vivo tests on pigs, of an already existing, simplified in vitro method, taking into [...] inal tract and available for absorption. An in vitro method for measuring the bioaccessibility of EDCs
Risk factors and markers for early detection of Alzheimer’s Disease: focus on early-life adversity, inflammation and lipid mediators – SOLID
cohorts as well as more than 10 established in vivo and in vitro mouse and rat preclinical models. We will
Toxicity to humans of ingested micro and nanoplastics combined to metallic environmental contaminants – PLASTOX
tal combinations will be evaluated on in vitro and in vivo models of the human intestinal and immune [...] the use of ISO standards, and will be digested in vitro using a model of human digestion. The sorption/
FUNCTIONAL PANCREATIC ISLET NETWORKS IN NUTRIENT HOMEOSTASIS IN MEN AND MICE – FUN-NET
endocrine pancreas plasticity and metabolic outcome in-vivo. Using CRISPR technology the group has generated [...] THE DETAILED OBJECTIVES are: OBJECTIVE 1: In-vivo exploration of cell-type influence on mixed nutrient [...] h fat diet (Leader HERRERA) OBJECTIVE 2: In-vitro exploration of cell-type influence on dynamic nutrient
Spatial regulation of RhoGTPase during cell division through 2 RhoGEF isoforms – Pebbles
analysis. Specifically, in vitro binding assays and GEF assays, combined with in vivo genetic interaction [...] activity. In parallel, in vitro lipid binding assays combined with in vivo examination of Pbl-A and B
Chromatin control of sperm nuclear compaction and shaping – ORTHOSPERM
(confocal, electronic, Super Resolution), in vivo and in vitro functional approaches, proteomics and biophysic
Gene therapies approaches for Charcot-Marie-Tooth diseases: targeting the right cell type and compartment – GENERATE
imaging strategies as well as behavioral testing, in vitro preparations (cellular models originating from rodents [...] rodents and patients with CMT) and in vivo transgenic mouse models. We believe the GENERATE project
Prevention and gene therapy of viral encephalitis using specific interferon-stimulated genes – ISG-therapy
the best hits will be tested in mice in vitro and in vivo using AAV gene transfer to target ISG expression [...] implement this strategy in animal models. First, an in vivo overexpression screen of ~60 ISGs will be conducted [...] conducted in zebrafish. This large cell type-specific in vivo screen will be made possible thanks to a novel
Lab-on-a-chip model of mucociliary clearance for the treatment of Inflammatory Lung Diseases – MucOnChip
ary to experiments performed In Vitro on lung epithelia and In Vivo on small animals. It has also significant
Novel bioprinting approaches for the creation of advanced pancreatic cancer initiation models – BioPrint_PaCiniMo
and progressive disease, for which advanced in vitro models are needed to enable decrypting of its initiation [...] control over the model design and replicate the in vivo precancerous niche. These tools can then be applied