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Towards a PREcise DIagnosis in Ciliopathies – PREDICT
endorgan involvement. These models will be tested in vitro using simple cellular assays based on fibroblasts [...] ived retinal and renal organoids, as well as in vivo using zebrafish models. Taking advantage of the
Multidimensional mechanistic investigations of trans spinal direct current stimulation in motor neuron disease. – DC4MND
modeling approach, how tsDCS current spread in vivo and in vitro given the geometrical and biophysical constraints [...] motoneurons after tsDCS by using cutting edge in vivo intracellular recordings of mouse spinal motoneuron [...] ation using cell biology, chemogenetics and in vitro electrophysiology. The experimental work will be
Towards the most accurate diagnosis and monitoring of Complement-mediated rare kidney diseases – COMPRare
kallikrein-kinin system and heme using both in vitro and in vivo models. The scientific consortium, from 6
Single cell sequencing and functional genetic analyses of ROS-induced Leishmania hybridization during sand fly infection – SFLeishHyb
frequency of hybrids generated in vivo is much higher than in vitro, showing that the vector gut environment [...] parasite and the vector, and a combination of in vitro and in vivo experimentation, I aim to decipher the impact [...] particularly adapted for Leishmania sexual mating. In vitro hybrid production opens unique possibilities of
Determining the role of SLC6A4 polymorphisms on the anti-depressant response: from causality to identification of molecular signatures and robust biomarkers – PolyDep
several experimental paradigms (in silico, in vitro and in vivo) to model key aspects of the disease. To
Molecular pathophysiology of iron homeostasis during anemia and targeted intervention – MARINADE
hepatokine is a potent suppressor of hepcidin in vitro and in vivo. Our preliminary data further indicated that
Conditioning mesenchymal stromal cells for immunomodulation in a model of autoimmune disease, Myasthenia gravis – CONDIMESO
immunomodulatory efficacy of cMSC and of their EVs in vitro and in our humanized animal model. For this purpose [...] immunomodulation capacities of cMSC and EVs in vitro using PBMC inhibition assay, the analysis of changes [...] (5) We will assess and compare the efficacies in vivo of MSC conditoned by either PBMC, or the optimal
Microscopic Image filaments' Curvature Extractor using Neural Networks in live cells – MICENN
play major roles in vivo. During mitosis, they appear highly curved compared to in vitro. It suggests that [...] Microtubule flexural rigidity was investigated in vitro, taking advantage of bright labelling, isolated [...] of recent deep learning progress to create an in vivo mapping of microtubule curvature as a proxy to rigidity
Cytoplasm fluidization by bulk actin rearrangements for organelle positioning – CytoActinPos
In a second work package, we will use in vivo and in vitro experiments to test how transport along m [...] motors. In a first work package, we will use in vivo magnetic tweezers to directly displace endogenous [...] cytoplasm of live large zygote cells, and develop in vitro and in silico reconstitutions of bulk actin networks
Self-Immolative Polymers for NIR- and UV-responsive Materials – SIPONIUM
UV-triggered and controlled drug release, in vitro and in vivo. To our knowledge, SIPONIUM is the first project