Self-Immolative Polymers for NIR- and UV-responsive Materials – SIPONIUM
Stimuli-responsive polymers have gained increasing interest in many domains; the ability to change their physicochemical properties, due to a stimulus, makes them relevant materials for several applications including biomedical and drug delivery systems. Based on these polymers, different forms of matrices and scaffolds have been developed and used for controlled drug release, such as particles, hydrogels, porous matrices and fibrous scaffolds. Various chemical structures of polymers were developed for this purpose allowing polymer-sensitivity to different stimuli: pH variations, heat, light, enzymes, chemical moieties etc. However, these systems show drawbacks and limitations such as a non-controlled and non-triggered biodegradation of the matrices or scaffolds within the physiological media and hence not well-controlled release, low penetration depth of the external stimulus, the intensity of the stimulus often depends on the fluctuations of the physiological media (e.g. pH or heat), a passive release which occurs before the application of stimulus, the control of the wettability is also a real challenge which affects the biocompatibility of these scaffolds.
To overcome these drawbacks and limitations, the SIPONIUM project aims to developpe new structures of Self-Imolative Polymers (SIPs), whose special feature is to undergo depolymerization in response to external stimulus. The strategy adopted consists in combining the special degradation mechanism of the SIP, with a deep penetrating stimulus (NIR) and tailored macromolecular architectures leading to control the wettability and the permeability of these materials. The polymers that will be prepared will be used to make for the first time, intrinsically sensitive electrospun nanofibers for both NIR-and UV-triggered and controlled drug release, in vitro and in vivo. To our knowledge, SIPONIUM is the first project developing the theme of SIPs in France.
Monsieur Kedafi Belkhir (Centrale Lille Institut)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Centrale Lille Institut Centrale Lille Institut
Help of the ANR 207,502 euros
Beginning and duration of the scientific project: March 2023 - 36 Months