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Quantitative Ultrafast Analysis by 2D NMR To Unravel Metabolic complexities – QUANTUM
Understanding metabolism is a major issue, as a better understanding of biochemical reactions in biological systems opens the way towards the development of biological and medical applications, such as new diagnosis tools. One of the numerous goals of analytical chemistry is to deal with such metabo
Ionogels for the Delivery of Drug-based Ionic Liquids – IDDILiq
A tremendous effort is currently being undertaken by the scientific community to develop drug delivery systems in which the release of the active substance is controlled “on demand”. The key-issue is to control the physical and chemical properties of the drug encapsulated. Indeed, most of the drugs
High field Enhancement of nucLear Polarisation In Noble Gases – HELPING
Hyperpolarisation of noble gases is generally performed at low magnetic field (a few milliteslas) and protocols for high-field use in science or applications include several sensitive stages to preserve nuclear polarisation. In practice temporary gas storage, transportation, sample handling or shutt
Copper chelators targeted at the liver: a innovative treatment of hepatic copper overload – COPDETOX
Metal overload plays an important role in several diseases such as Wilson’s disease, a major genetic disorder of copper metabolism in humans. The Wilson’s disease is a rare disease (~ 1000 cases in France, 10000 in the EU and 10000 in the USA) due to the impairment of a protein responsible for the e
Development of a monitoring device of the osseointegration of implants in the osteo-articular system – WaveImplant
The aim of this work program is to be ready for the clinical development of the technology using a prototype in line with the market expectations. The program is going on as expected and no particular difficulty is met. Two persons have been hired and two master students work on the subject. An impo
Microglial Implication in Modulation of Inflammation in leech CNS – MIMIC
Microglial cells are rapidly recruited to a lesion site in the Central Nervous System (CNS) either in mammals or in leech. The program that we develop in the leech aims (i) to characterize the chemotactic factors which are responsible of the microglia migration (ii) to investigate the time-course of
Palaeopollutions and human impacts on the Tiber delta – POLTEVERE
The aim of the POLTEVERE project is to assess the pollutions generated by the cities of Rome, Ostia and Portus throughout the course of history, as well as to reconstruct the evolution of the environment of the Tiber delta, relating to human occupation. The main objectives are firstly to define the
Hunter-gatherers facing environmental changes: the Magdalenian of the Atlantic coast during the Late Glacial (18,000-14,000 cal. BP) – MAGDATIS
Being nomadic and living only from hunting and gathering, Paleolithic people are often perceived - by scholars and by the general public alike - as highly depending on the variations of their natural environment. And indeed, one of the main issues in Paleolithic archeology is to understand the relat
cOmetary GRains and Early Solar System Evolution: Isotopic analyses of cometary polar micrometeorites – OGRESSE
Analysis of extraterrestrial material allows approaching various fields of research spanning from stellar nucleosynthesis in generations of stars prior the Sun to planetary evolution. The ORGRESSE project to tackle fundamental questions regarding: i) the interstellar component present in cometary ma
Revisiting the Population Genetics and Genomics of partially clonal organisms – CLONIX
Clonal reproduction (also named asexuality, i.e. reproduction without genetic modification) is a reproductive mode that has been adopted (at least partially) by a wide variety of organisms across the Tree of Life. Understanding their evolution and dynamics requires a good appraisal of the extent and
