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Cell-type specific determinants of epileptic syndromes associated with KCC2 mutations – EpiK
Altered neuronal chloride homeostasis is emerging as a hallmark of neurological and psychiatric disorders, including epilepsy, autism spectrum disorders, and schizophrenia. Defects in the expression or function of the cation and chloride cotransporters KCC2 and NKCC1 are associated with these disord
Cellular Plasticity in ageing – iCELLPLASTICITY
Ageing has long been recognized as a major risk factor for many diseases as it associates with dramatically increased chronic diseases, including cancer, diabetes, and neurodegenerative diseases. An emerging view in the ageing research field suggests that ageing may be the underlying driving force f
Cellular Regeneration Articulated with Chromatin Kinetics – CRACK
Context: Regenerative healing allows reconstruction of an identical body part following wound or loss. Whereas mammals do have a limited ability to accomplish such processes naturally, this pales in comparison to spectacular cases of full body plan reconstruction following decapitation in planaria
Cellular and Molecular characterization of Extracellular-Vesicle (EV) and Extracellular-Mitochondria (EM) delivery – EVEM
Extracellular vesicles (EVs) and Extracellular Mitochondria (EMs) are two emerging types of intercellular communication vectors that are poorly- or uncharacterized, respectively. This is especially true when considering the cellular and molecular aspects enabling their uptake by recipient cells.
Cellular and molecular analysis of GnRH-1 neuronal development: insights into hypogonadotropic hypogonadisms. – MUSeS (Migration Under Semaphorins Stimu
Infertility is a devastating condition that affects several million couples worldwide. Experts forecast that infertility will double in Europe over the next decade. There is thus an urgent need to elucidate the molecular and cellular pathways underlying reproduction and, in particular, the neuroendo
Cellular metabolism of Treg in the control of chronic inflammatory diseases – MetaTreg
Cellular metabolism is becoming an emerging field of investigation in immunology. For instance, it has been recently shown that a switch from oxidative phosphorylation to aerobic glycolysis in conventional T cells is a prerequisite for their proper activation. CD4+Foxp3+ regulatory T cells (Tregs) p
Cellular role and mode of action of two pivotal bacterial protein-kinases – PiBaKi
More and more bacteria are resistant to currently used antibiotics. Our work should allow characterizing new regulatory mechanisms essential for the bacterial cell physiology. This fundamental knowledge is a prerequisite to initiate inhibitory strategies of these regulatory mechanisms and to develop
Cellular, molecular and systems-level mechanisms underlying the establishment of a brain cognitive reserve in a mouse model of Alzheimer’s disease – CoRehAlz
The “cognitive reserve” model suggests that individuals with greater brain reserve capacity (i.e. with higher level of education or occupational attainment) may develop resilience to neurodegenerative damage and optimize behavioral abilities through differential recruitment of neural networks and/or
Center for Innovative Nanostructured Foils and related applications – In-Fine Consolidation
The University of Technology of Troyes and SURYS have set up a joint laboratory for the development of films and nanostructured surfaces on a large scale. The objective of this center called In-Fine (innovative center for industrial Nanostructured film) is to encourage the emergence of new products
Center for Innovative Nanostructured Foils and related applications – IN-FINE
The University of Technology of Troyes and Hologram Industries wish to set up a joint laboratory for the development of films and nanostructured surfaces on a large scale. The objective of this center called IN-FINE (innovative center for industrial Nanostructured film) will be to encourage the emer
