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Dual Profiling of the SARS-CoV2 interplay With the INnate immune response pathway – DARWIN
COVID-19 has emerged in December 2019 in Wuhan, China, caused by a novel RNA virus: SARS-CoV-2. As of March 22 2020, ~300,000 cases of COVID-19 and nearly 12,000 deaths (fatality rate ~4%) have been reported in the world. The high proportion of cases requiring respiratory assistance in intensive car
Analyse et Calcul des Effets de Rugosité sur les Ecoulements – RUGO
The RUGO project stems from questions raised by the study of gas and liquids near irregular surfaces. These questions come from various domains of fluid mechanics, from microfluidics to oceanography, and involve a large range of scales. Despite this variety of physical settings, some typical problem
Photopolymérisation de microstructures 3D pour le contrôle de l'architecture et des communications multicellulaires – 3DPHOTOPOL
Most methods in modern cell biology are implicitly based on the assumption that the behavior of a cell is predominantly determined by its individual biochemical and genetic properties. Moreover, complex processes such as tumorigenesis, are studied by methods that make it quite difficult if not impos
Acousto-optic Light Patterning for the Imaging of Neurons and Stimulation – ALPINS
In the last decade, cellular and systems neuroscience have experienced a thorough paradigmatic shift following the optogenetic revolution. Optogenetics provides the capability to record and modify the activity of genetically defined cell types in the brain, through light-activated protein-encoded re
Advanced Processing of Hyperspectral Images and Sequences – APHYPIS
Recent technological advances created a new generation of hyperspectral sensors, be it for satellite remote sensing or in situ monitoring. The corresponding data open the door to numerous potential applications with a high societal impact (defense and security, biomedical imagery, monitoring of the
Specialized translational Complexes to Control Translation during Regeneration – SPECCTRE
Central Nervous System (CNS) neurons are not able to regenerate their axons after injury. This discrepancy is due to a dual mechanism: first axonal growth capability decreases during development and second, the lesion itself diminishes regenerative capabilities and induces neuronal death. Numerous s
Emergence of inhibitory plasticities in hippocampal area CA2 underlying normal and pathological develpment of social memory during adolescence – PlasticAdo
Adolescence is a transition period characterized by considerable brain remodeling leading to behavioral and cognitive changes including social cognition. This developmental period is also characterized by a high sensitivity to environmental factors that can facilitate the emergence of psychiatric di
High-throughput Computation of Defects in Semiconductors – CODIS
We propose a large-scale computational screening of defects in semiconductors. The project will be the first to inter-relate growth conditions, defect types and concentrations, and functional transport properties. The study will combine several approaches developed by the two project partners and st
Crack initiation in Ni under fatigue and hydrogen flux – CRACKHINIT
One of the elementary physical mechanisms implied at the first stage of corrosion fatigue processes in presence of hydrogen in nickel is investigated during the CRACKHINIT project. Here, we focus on the hydrogen embrittlement phenomenon during fatigue, which has many implications for the durability
Digital Mueller Polarimetric Colposcopy For High-Performance Detection Of Premature Birth – DigitMC-PB
Prematurity represents the first cause of perinatal mortality and morbidity worldwide. The estimated rate of prematurity is about 6% in France and Europe and it is two times greater in US. This rate remained stable over the last two decades, despite the improvement of diagnosis by using transvaginal
