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Deciphering the function of proteins involved in ribosome biogenesis – BIORIB
In eukaryotes, the ribosome cannot assemble spontaneously from isolated components. Ribosome biogenesis takes place in the nucleolus, a specialized nuclear compartment, and requires the coordinated action of over 200 non ribosomal proteins. The function of these non ribosomal factors is generally in
Bacterial small regulatory RNAs: how to reconcile target specificity and pleiotropic action – SalsARN
Small non-coding RNAs have emerged as one of the most important classes of regulatory molecules in all living organisms. In bacteria, small RNAs (sRNA) exert their regulatory function by base-pairing with sequences near the translation initiation codon of target messenger RNAs. Most often, formation
Refolding G protein-coupled receptors: a novel approach using polymeric surfactants – Refolding GPCRs
In spite of their key physiological roles, an understanding of the molecular basis for the function and dysfunction of membrane proteins (MPs) is rarely available. A main obstacle to establishing the atomic structure of MPs is their low natural abundance and the absence of established methods to ove
Yeast Division in Microdroplets – YEASTDROPLETS
A human body is composed of about 10tothe13 to 10tothe14 cells, and major biological processes such as cellular differentiation, immune response, offspring identity, or cancer emergence arise from single or very few cells. It is therefore essential to investigate the probabilistic rules of such rare
Deciphering the complex evolution of genes involved in human adaptation to diet – NUTGENEVOL
One of the greatest challenges in human evolutionary genetics is to elucidate the evolution of biological multigenic traits. The nutritional transitions that occurred during human evolution represent major changes in our environment. One of these major transitions is the emergence of agriculture in
Coordinating cell division and DNA replication: interplay between Cdc2, Myt1 and a new player, Greatwall – MyGreatOocyte
Our project aims for understanding the control of two crucial periods of the cell cycle, M- and S-phases. This project is based on a physiological model system, the meiotic divisions of Xenopus oocyte, broadly used to study cell division. The first objective is to unravel the molecular mechanisms th
Mechanisms and physiopathology of receptor- and ß-arrestin-controlled chemotaxis – arrest&chemotax
Chemotaxis is an important physiological property of many cell types, consisting of the ability to move in the direction of gradients of external signaling molecules. This process regulates the coordinated cell movements that produce morphogenesis during development, participates in tissue wound hea
Frontiers of recognizability – FREC
One of the challenges of computer science is to manipulate objects from an infinite set using finitary means. The central concept that has emerged in response to this challenge is an algebraic concept of recognizability. It offers unparalleled closure and algorithmic properties, matched with usef
Systèmes catalytiques écocompatibles à base de biopolymères et de liquides ioniques: catalyseurs homogènes hétérogénéisés efficaces, recyclables et réutilisables - Ecofriendly transition metal catalytic systems based on renewable biopolymeric support an – BIOPSIL
Awareness of impact of chemistry on the environment favors the emergence of new industrial processes that respond to various criteria: biodegradable materials, catalytic processes in high yield under mild conditions, no release of heavy metals, use of raw materials from renewable resources, recyclin
Coupling between Ionic and Electronic Transport in Single-Walled Carbon Nanotubes – IONESCO_Ukraine
Efficient coupling between electronic and biological systems requires an interface for converting electronic signals into ionic (or chemical) signals, and vice versa, ideally with high sensitivity and speed. Unfortunately, the performances and functionalities of present electro-ionic devices poorly
