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Remodeling of cellular machineries during quiescence – Quiescent Tools
Most cells spend the majority of their life in quiescence, a state defined as a temporary and reversible absence of proliferation. Establishing quiescence and being able to re-enter the proliferation cycle must be tightly orchestrated to avoid pathological cell proliferation. Hence, deciphering the
Innovative manufacturing Route for Intermetallic alloys by spark plasma net Shaping – IRIS
This project is devoted to the net shape manufacturing of two intermetallic materials by means of an emerging powder compaction technique called SPS (Spark Plasma Sintering). Application of this technology to high performance intermetallics that are difficult to manufacture or to form using conventi
Adaptive ultrafast laser processing techniques for photonic and optical applications – AdPRO
Following the demand for functionalization of optical materials, laser-induced photoinscription opens up new perspectives for emerging photonic applications. The challenge is to design dielectric properties and add specific optical functions to compact, integrated optical devices. Nevertheless, the
Topologically protected states in double nanowire superconductor hybrids – SuperTop
Topological quantum computing (TQC) is an emerging field with strong benefits for prospective applications, since it provides an elegant way around decoherence. The theory of TQC progressed very rapidly during the last decade from various qubit realizations to scalable computational protocols. Howe
Small GTPase Structure/Function Relationship – GTPase-SFR
The « small GTPase structure/function relationship » project emerged one year ago in the Structural Motility group at the Curie Institute. Our goal is to gain 3D structural information on several small GTPases of the H-Ras superfamily that are involved in cancer. We have chosen to study these protei
Ezrin mediated membrane cytoskeleton coupling : studies in biomimetic systems – EzrinBiomim
The aim of this project is to understand at the molecular level the link between membrane structures and the actin cytoskeleton. Ezrin, member of the ezrin/radixin/moesin (ERM) family, is a membrane cytoskeleton linker involved in the cellular morphogenesis and motility. ERM proteins are localized i
Antisense sequences delivery for therapeutic intervention on messenger RNAs – GENESPLICE
Up to 50% of disease-associated mutations in humans affect the pre-mRNA splicing and maturation processes, by inactivating splicing signals, creating cryptic ones or modifying binding sites for splicing regulators. They result in exon skipping, inclusion of cryptic exons or intron retention, and in
Parfums et Résidus Huileux de la Méditerranée Occidentale – PERHAMO
1. Scientific context and project objectives : From the Bronze Age to the Archaic Period perfume played just as decisive a role as wine did when it came to developing long distance trading and to the emergence of the elite. The sources that allow one to tackle the economic and cultural roles of perf
Marchés de l'art en Europe 1300-1800, émergence, développement, réseaux – M-Art
Art markets in Europe 1300 – 1800 Emergence, development, networks Over the past 20 years, the history of art markets has been substantially developed thanks to the collaboration of researchers from different fields (historians, art historians and economists). The study of the economic and social co
Acoustique picoseconde pour l'élastographie cellulaire et l'évaluation de l'adhésion sur biomatériau – PicoBio
In the field of osseous and/or vascular substitution it is necessary to develop innovative techniques to satisfy the request for substitutes and to find solutions combining availability, perenniality and biosecurity of the implants. One of the main strategies in this area of research is to make the
