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Biosynthetic, structural and functional characterization of Rum C peptides, a family of bacteriocins as viable alternative to conventional antibiotics – RUMBA
Since the discovery of penicillin in 1928, humans have widely developed and used antibiotics to combat microbial infections. However, inappropriate and excessive use of these molecules has led to the emergence of pathogens resistant to all classes of antibiotics. According to the World Health Organi
BirdIslandGenomic: A genomic perspective on the evolution in small populations of island endemic birds – BirdIslandGenomic
Oceanic islands provide great opportunities for studying biological evolution. In this project, we propose to investigate island evolution from the genomic point-of-view. Understanding the influence of population size variation on molecular evolution is currently a major topic in the field. Since is
Birth of a killer: genetic factors and metabolic adaptations required for the emergence of epidemic tuberculosis bacilli – TBemerg
Mycobacterium tuberculosis has evolved to be among the most deadly human pathogens, estimated to infect one-third of the world’s population, and causing 9 million new tuberculosis cases and more than 1.5 million deaths per year. In contrast, strains of Mycobacterium canettii that also can cause huma
Bistable hybrid nanostructures – NanoHybrid
This project emerges at the crossroads of several new ideas based on our recent results, which were obtained in the frame of different national and international projects arriving to their final stages. At present, we possess a unique know-how at the international level in the synthesis of spin cros
Black Hole Microstate and de Sitter Landscapes in String Theory – Black-dS-String
String Theory is the most promising candidate for a theory that unifies all the forces that exist in nature, and could therefore provide a framework from which one may hope to derive all the observed physical laws. However, String Theory lives in ten dimensions, and to obtain real-world physics one
Blood-brain barrier crossing of conventional and new antidotes to treat organophosphate poisoning. – BHE-OP-Antidotes
Organophosphates (OPs) constitute a class of synthetic molecules still widely used as an insecticide but also as chemical weapons. This class has been the subject of numerous investigations by the chemical industry in search of pesticides that are more effective and potentially less harmful to the e
Body representation plasticity in typical and atypical motor development – BODYS
Developmental coordination disorder (DCD), commonly known as dyspraxia, is a major developmental disorder that impacts the autonomy of 5% of the population in several daily life activity and education. While historically attributed to problems of motor control and coordination, recent evidence point
Boosting respiratory innate immunity to treat pneumonia caused by antibiotic-resistant bacteria – BIP
Bacterial pneumonia is a leading cause of morbidity/mortality worldwide. Antibiotics constitute the standard of care but face with the emergence of antimicrobial resistance (AMR) and the curative failure. The project aims at assessing an adjunct to antibiotic therapy as an emerging concept of overco
Boranes, hydrures complexes vecteurs d’hydrogène: stockage, hydrolyse et synthèse par recyclage – BoraHCx
The present energy and environment context is rather favourable to the development of alternate and/or new energies, like hydrogen. Nevertheless the issue regarding its storage hinders the development of a hydrogen economy. Today several storage solutions have been envisaged. Among the most promisin
Borna disease virus replication complex: structure, neuronal function and interactomics – Bavarian
Borna disease virus (BoDV), a single-stranded RNA virus of negative polarity, has puzzled researchers for decades, because of its neurotropism and non-cytolytic multiplication strategy. Its recent recognition as a zoonotic agent causing severe encephalitis and brain dysfunction has provided further
