Search
Etude de la relation hôte pathogène du système Acanthamoeba/Mimivirus – MIMIVIRUS
The discovery of Mimivirus and deciphering of its 1.2Mb genome sequence sent a shock wave through the community of virologists and evolutionists. The size, gene content, and phylogenetic characterization of the virus genome challenged many accepted ideas about what virus should look like, and where
Total synthesis of Amphidinol 3 – AMPHI3
The amphidinols (AMs) are a fascinating group of biologically active polyketide matabolites isolated in 1991 from the marine dinoflagellates of the Amphidinium species. Among them amphidinol 3, isolated by Yamumoto (12mg from 440L in culture) has emerged as an important synthetic target because of i
Nouveaux Inhibite Nanomolaires du Protéasome en Chimiothérapie du Cancer. Salinosporamides et analogues – proteasome
The goal of this investigation is to find new anticancer therapies and the success of Bortezomib in the treatment of multiple myeloma provided evidence that proteasome inhibitors can be effective clinically. Salinosporamide A, recently isolated from marine sediments, is a novel potent proteasome inh
Characterizing the deep roots of Gender Inequalities through molecular archaeology – GenIn
GenIn proposes a multi-disciplinary approach aiming at better understanding the deep roots of gender inequalities by exploring the status and life of women during the transitional period between the Neolithic and the Bronze Age in occidental Europe. More specifically, GenIn aims at leveraging the la
A transdisciplinary exploration of the Acheulean through bone surface modifications and the cutting implements that produced them – BSMART
The Acheulean was one of the most successful Palaeolithic cultures lasting for more than 1.5 million years, spreading across three continents, and in association with at last five different hominin species. The Acheulean is marked by the emergence of cutting implements in larger formats (Large Cutti
Bands of Brothers: Institutionalising Fraternal Communities – BOBIFC
This research in Historical International Relations (IR) examines how nations became the dominant political communities shaping the international order. While Benedict Anderson’s concept of the nation as an ‘imagined community’ has been influential, he did not provide a framework for imagination, im
NMR Crystallography from Protons – NMR-X
Structure activity relationships are at the heart of modern chemical sciences. For example most rational drug design strategies used in the pharmaceutical industry take knowledge of the three dimensional structure of a target protein (Wüthrich, Nobel Prize 2002) and the interaction site of candidate
New methods in mass spectrometry imaging for the study of the Alzheimer's disease – MASS-IMAGE
TOF-SIMS (Time-of-Flight Secondary Ion Mass Spectrometry) mass spectrometry imaging provides access to the chemical composition of the surface of a sample with an accuracy of one micron, without any a priori on the mapped species. The main objective of this project was to greatly improve with analy
Synthetic Biological Systems : from Design to Compilation – SYNBIOTIC
The project kickoff meeting was held on Friday, November 3, 2010. Emmanuel Sabban (ANR representative) give an introduction and each partner has explained the content of the tasks in progress. 5 meetings were held in 2011. Date Location Topic Partners attending the meeting EVRY 03/11/
Dependability-focused Evaluation of Sensor Networks – MURPHY
Murphy aims at easing the development of dependable and pervasive applications built on top of robust wireless sensor networks, Two national and international partnership have been established. 3 workshops have/are actually organised in addition to scientific publication in international and natio
