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Phytoextraction of metals in contaminated soils: transfer and sequestration of cadmium and zinc in the hyperaccumulating plant Arabidopsis halleri – PHYMET
The aims of the project are to determine the mecanisms of accumulation and transfer of Zn and Cd in A. halleri from metallicolous and non metallicolous origins, focusing on the leaves and xylem sap, and to test if these mecanisms change with the capacities of tolerance and accumulation of the plants
HDL as markers of pathological remodelling and anti-protease vectors – HDLomics
Beneficial effects of HDL in atherosclerosis remains chiefly associated with reverse transport of cholesterol, even if other anti-atherogenic properties are well documented (anti-oxidant, anti-inflammatory or anti-thrombotic effects). Proteomic approaches have shown that HDL are more than lipids ass
Quantitative Ultrafast Analysis by 2D NMR To Unravel Metabolic complexities – QUANTUM
Understanding metabolism is a major issue, as a better understanding of biochemical reactions in biological systems opens the way towards the development of biological and medical applications, such as new diagnosis tools. One of the numerous goals of analytical chemistry is to deal with such metabo
DEsign of Solid state experiments for Ionization of copolymeRs in mass Spectrometry – DESIRS
Since the development of soft ionization techniques which have enabled the production of intact high molar mass ions into the gas phase, mass spectrometry has revolutionized the characterization of synthetic polymers. Matrix Assisted Laser Desorption/Ionization (MALDI) has quickly emerged as the met
Millimeter reactors with micro-structured-Matrix for multi-phase catalytic reactions – MILLIMATRIX
The emergence of microreactors and process miniaturization over the past decade has provided a potentially new platform for accelerating the development of next-generation catalysts and multiphase catalytic process technologies. Due to increased process intensification offered by the microreactors,
Nanostructured Multifunctionnal Electrodes (NAMUEL) – ENaMU
The present project aims at the fundamental understanding of NAnocomposites MUltifunctionnal ELectrodes (NAMUEL) made of electronically conducting polymers (ECP) or pi-conjugated oligomers with aligned carbon nanotubes (CNT). Among the numerous possible applications, these NAMUEL will be studied mai
Tumor-specific Multi-Operating Radiotracers targeting Telomerase And G-quadruplex – TuMOR TAG
Anticancer agents that target DNA are currently the most efficient drugs in clinical use. Their mechanism of action is multiple, either affecting the DNA itself (i.e., alkylating or cross-linking agents, like cisplatin for instance) or trapping proteins normally bound to DNA (like topoisomerases, su
Tools based on coordination chemistry to study the role of H2S in biology. – CoordH2S
Three goals are targetted: i) the development of fluorescent sensors of hydrogen sulfide in solution, ii) the development of slowly-releasing hydrogen sulfide in solution, and iii) studies aiming at elucidating the reactivity of H2S towards some species present in biology. Two probes opera
N-heterocyclic carbene–nickel(II) catalysts supported on materials of SBA-15 type for C-H bond functionalization – SBA-15-NHC-NiCat
Compelling economic and environmental demands are presently driving fundamental changes in the design of chemical processes. In this regard, the quest for reactions that are satisfying from both cost and atom economy has never been as intense as nowadays. In addition, the relative dearth of non-poll
New Bio-inspired Catalytic Systems – NCiS
In the past 10 years, biocatalysis has emerged as a wonderful tool with broad applications for the synthetic organic chemist. Based on selective and eco-compatible processes, biocatalysis is usually associated with the use of enzymes. During the last five years, however, considerable efforts have be
