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Cotranslational processing mechanisms: towards a dynamic 3D model – RIBO-Dyn
Among non-ribosomal proteins, ribosome-associated protein biogenesis factors (RPBs) are molecules acting as soon as a nascent polypeptide reaches the tunnel exit of the ribosome. RPBs are involved in the so-called cotranslation events including protein folding, modifications and/or translocation in
Observing the T cell receptor (TCR) activation in real time: monitoring the intracellular domain orientation dynamics of the receptor complex in live cells with polarized time-resolved fluorescence imaging – ReceptOrient
We study the process of activation of TCR - initiation of intracellular signaling cascades following receptor engagement by pMHC ligand. Recent studies in model systems suggest that an essential early step in the activation of the TCR involves conformational change / re-orientation of the CD3epsilon
Molecular ortheses for the crystallization of membrane proteins. Application to multi-drug efflux pumps. – X-Or
Membrane proteins have widely diverse, essential functions and constitute a major class of molecular targets for therapeutic research. However, membrane proteins remain challenging for structural studies as all steps, from expression to structural studies, are potentially complicated by their obliga
DEAD-box helicases: function, specificity, and mechanism of action – HelicaRN
This research project proposes to study the DEAD-box family of helicases, which are enzymes that are essential for the biology of RNA in nearly all organisms. Indeed, the inappropriate expression of these enzymes can provoke cancer in humans; this reflects the capacity of these enzymes to modify or
Decision, confidence, and compulsive actions: the neural bases of metacognition and its dysfunctions in obsessive-compulsive disorder – DECCA
Our project uses behavioural studies to explore the neural basis of metacognition, that is, the introspective processes which lead to one's degree of confidence in one's decisionsNotre projet explore par des études expérimentales les bases neurales des processus . A process which, therefore, drives
CYCLOsporine A neuroprotection in a Primate Stroke model with imaging – CYCLOPS
Stroke is the third cause of mortality and the first cause of handicap. Thrombectomy is about to change patient care in emergency. In this context close to myocardial ischemia-reperfusion (IR), treating reperfusion injury is crucial as it contributes to cell damage extension and to inflammation. In
Combining atomic-resolution structure with high-resolution tracking in cells to dissect regulation and mechanism of the MKlp2 kinesin – MITOKINESIN
Mitosis involves the complex coordination of cytoskeleton rearrangements in which the action of nanomotors is temporally and spatially controlled to precisely divide chromosomes and cytoplasm of a cell. While basic features of molecular motor function have been understood, the most burning open ques
REdox active Molecular layers with Ions for Nanoelectroionics Devices – REMIND
REMIND is focussed on multifunctional ultrathin organic films with mixed electronic and ionic conductivity and on emerging devices as defined in the ITRS roadmap within the resistive memory theme. It develops building blocks that can be used in high added value domains and are upstream for nanoelect
Digital Atlas of Art History – ARTLAS
To write a “global” history of the arts, we cannot merely add chapters on peripheries without changing the canonical narrative. We have not only to broaden our geographic scope, but also to connect the new regions to what we already know about North-Atlantic regions, and to rethink the hierarchical
Credible Gesture Interaction – INGREDIBLE
The goal of the project INGREDIBLE is to propose a set of scientific innovations in the domain of interactions between humans and virtual actors. The project aims at developing a prototype of an autonomous virtual actor capable a dynamic affective bodily coupling with a human whose gesture are analy
