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Memory of single odorant or odorant mixture in the newborn rabbit: Time-course, mechanisms and functions – MEMOLAP
Perception of food results from the detection and integration of complex odours. This is true from a very young age. Although decisive in terms of health and well-being, the mechanisms governing this perception remain weakly known. In mammals, maternal odours help the newborn to locate the nipples a
Impact of fatty acids on infection by low GC% Gram positive pathogens – FattyBact
Bacterial pathogens are usually tested for antibiotic or stress sensitivities when grown in laboratory medium and conditions. Our results indicate that bacterial expression and behavior is significantly altered by exogenous fatty acids (e.g., in blood, organs, or foods). This project aims to re-exam
Neuro-Immune Interactions during Neurodegeneration in Parkinson’s Disease: Role of the Chemokine Network – ParKemoS
Cerebral inflammation develops in the brain of patients with Parkinson's disease and is though to contribute to neuronal death and disease progression. Therefore, tackling this inflammation is an important therapeutic goal. However, to achieve this goal, it is necessary to understand the neuro-immun
A novel, integrated approach to the mechanisms and dynamics of episodic memory: from genes to cells and neural network properties. – MolCellCog
Remembering past personal events of life, sometimes in great details, contributes to our individual construction and determines our relations with others. This capacity of our brain to store memories and to relive them during recall is known in humans as ‘episodic memory’, the memory of what happene
Physiology and Evolution of the Neural Control of Respiration – GenRESP
This project is divided in two parts. The first and main part, “Genetic dissection of central respiratory circuits” is a concerted attempt at teasing apart neuronal circuits involved in respiratory functions. More precisely, our work will focus on the retrotrapezoid nucleus (RTN), a group of interne
The potassium-chloride transporter KCC2 : a new target for the treatment of neurological diseases – KCC2-SCI
A decrease in synaptic inhibition –disinhibition- appears to be an important substrate in several neuronal disorders, such as spinal cord injury (SCI), neuropathic pain... Glycine and GABA are the major inhibitory transmitters in the spinal cord. An important emerging mechanism by which the strength
Molecular interactions involved in bacterial mitosis – BactMit
Bacterial proliferation relies on a series of essential processes such as genome expression, replication, genome segregation and recombination. By contrast to most of them, the comprehension of genome segregation is still unclear, and the molecular mechanism that drives active separation of DNA mole
Multiscale complexity of functional dynamics in visual cortex – Complex-V1
One of the characteristics of neural activity in neocortical networks is that there is a considerable level of self-sustained ongoing activity, which exhibits highly complex but structured spatiotemporal patterns of action potentials and whose irregularity in time is often interpreted as "noise". In
Function and Regulation of Telomeric Transcripts – FURETT
Telomere length is tightly regulated and decreases during aging. Changes to this regulation are associated with genetic diseases, malignancy and cellular senescence. It is therefore important to identify factors involved in controlling telomere length and function. From this perspective it was
Fabrication and advanced caracterizations of all-solid state micro-supercapacitors for pulsed regimes in severe environments – ARTEMIS
ARTEMIS is part of a global development project focusing on energy micro-storage for autonomous and connected objects. For the past ten years, the present consortium has been developing and manufacturing energy storage micro-sources with small mass (from 0.2 to 20 mg) and surface (from a few µm² to
