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Multimodal Fluorescence Light Sheet Microscopy (mFLSM) for in toto imaging of embryonic development – MFLSM-intotomorph
An embryo is shaped by a complex sequence of cell processes and morphogenetic events that are highly regulated both in time and space. Many of these mechanisms, such as collective cell migration, tissue invagination, or cell intercalation, are stereotypical and occur in every organisms. Advances in
Structure and dynamics of bacterial biofilms: from single cells to collective phenomena – FILMOTIL
Bacteria are unicellular prokaryotic microorganisms. They are everywhere and are an important part of the terrestrial biomass. As for most living species, community is necessary for their survival: bacteria self-organize collectively in complex architectures adsorbed on interfaces, the so-called bio
Mechanics and function of immune cells studied at the single molecule level – ImmuPhy
We aimed at evaluating the contribution of mechanics to the spatio-temporal regulation of cell polarity in B cells by using an innovative interdisciplinary approach –which combines single molecule experiments in live cells (single protein tracking) and force measurements. Our approach will ultimatel
Molecular basis of the vectorial transport of sterol – SterTrans
Sterol is a lipid of vital importance whose accurate distribution in cells results from a combination of synthesis and transport mechanisms between organelles. However, the molecular bases of these transport mechanisms remain largely unknown. The aim of our project was to demonstrate that several pr
Cellular and molecular analysis of GnRH-1 neuronal development: insights into hypogonadotropic hypogonadisms. – MUSeS (Migration Under Semaphorins Stimu
Infertility is a devastating condition that affects several million couples worldwide. Experts forecast that infertility will double in Europe over the next decade. There is thus an urgent need to elucidate the molecular and cellular pathways underlying reproduction and, in particular, the neuroendo
Molecular mechanisms underlying the coordination of cell growth and cell division – Growth and Division
Diverse cell types, from yeast to mammalian cells, often exhibit a dynamic pattern of growth throughout the cell cycle, dramatically changing cell polarity as cell cycle transitions occur. Communication between the cell cycle machinery and cytoskeletal components that organize the secretory apparatu
Physical and functional plasticity of proteasomes. – PLASTIZOME
The proteasome system has become increasingly recognized as a controller of numerous physiological processes, including signal transduction, DNA repair, chromosome maintenance, transcriptional activation, cell cycle progression, cell survival, and certain immune cell functions. This is in addition t
Connectivity Of Marine POpulations Application to the South Lagoon of New Caledonia – COMPO
In this project, we propose to study larval transport and population connectivity of a fish (damselfish, Dascyllus aruanus) and an invertebrate (giant clam, Tridacna maxima) species in the South Lagoon of New Caledonia (SLNC) using three emerging and complementary approaches: (1) parentage analysis
Genetic Dating in the Post-Genomic Era – DATGEN
The advent of high-throughput genotyping technologies has revolutionized evolutionary biology and genetics. These fields are now inundated by massive quantities of data, as determining dense sets of genotypes from individual genomes is no longer an overly expensive and difficult task. In the next fe
Polyion complex micelles for siRNA delivery in immature dendritic cells: polymeric vectors for ex vivo gene silencing in arthritis. – DenSicelles
Dendritic cells (DCs) are professional antigen-presenting cells that play a key-role in maintaining the balance between immunity and tolerance. There is a great deal of interest in how DCs might be exploited as a form of immunotherapy to induce immunity or to restore tolerance. The final goal of thi
