Search
Mitochondrial calcium homeostasis in the control of arrhythmia associated with metabolic cardiomyopathy – CALMOS
The control and the regulation of the mitochondrial Ca2+ homeostasis is a primary sensor of the cardiac metabolic disorder. We here propose that (i) MCU expression, structure and function integrates cardiac metabolic flexibility, (ii) the MCU composition dynamically affect mitochondrial Ca2+ homeost
Water-soluble aza-BODIPY platform for multimodal imaging and trackable therapeutics – WazaBY
Among the different disciplines in medical imaging, molecular imaging is an emerging powerful tool, which enables to detect pathophysiological changes in living subject at the cellular and molecular level. More particularly, optical imaging (OI) is the method of choice for in vitro and ex vivo studi
Controlled Computation of Point-Defect Characteristics in High entropy Alloys – CoCoA
Due to their high number of components at high concentration and to their disordered behavior, HEAs are a challenge for numerical simulations. In particular, point defect properties in these materials are no longer single values but correspond to statistical distributions. Ideally, ab initio calcula
MAGnetism InduCed VALLEY polarization in large scale 2D materials – MAGICVALLEY
The solution to reach a sizeable and robust valley polarization in TMD monolayers that we propose in this MAGICVALLEY project is to use 2D layered ferromagnetic materials allowing for a van der Waals (vdW) stacking with the MX2 (M=Mo,W and X=S,Se) monolayer and an exchange coupling through the vdW g
Coherent High Q Micro-resonator Blue Light Sources – COMBO
The project is divided in three main objectives. The first objective will draw up a panorama of the linear and nonlinear properties of WGMR in the blue range. A particular focus will be done on fluoride crystalline resonators identified as best candidates for the realization of either linear or nonl
End-to-End Neural Approaches for Speech Translation – ON-TRAC
The ON-TRAC project aims to explore emerging technologies from the field of deep learning in order to design, implement, experiment and disseminate a new approach to automatic speech translation that overcomes the constraint previously exposed (no transcription of the speech in the source language).
Unraveling modular information processing in cerebellar microcircuits – MicroCer
We postulate that targeting and identifying individual cerebellar modules will establish the fundamental rules in functional synaptic organization of the cerebellar modular system. Intramodular and communication between modules could then be discriminated for electrophysiological studies. Our idea i
Glia, Glutamate and Chemosensory Behavior – GGCB-2010
For decades, glial cells were largely neglected in neuroscience. Although glia total number is considerable in the adult human brain, they were traditionally been viewed as support cells for neurons. Recent emerging data are more and more changing this point of view. Our previous work on Drosophila
Deciphering antigen receptor-mediated NF-kB – DARN
Activation of NF-?B relies on non degradative K63-linked ubiquitination of key adaptors (NUTs, NF-?B ubiquitinated transmitters). However, the enzymes in charge of catalyzing NUTs ubiquitination and deubiquitination upon antigen receptor engagement are unknown. Our projects want to identify these fa
Sex chromosome and sex determination evolution in mammals – SEXYMUS
The project SEXYMUS will focus on different aspects of sex chromosome evolution The research program is organized into three main questions: - How do new sex determining systems evolve and what are their genic characteristics? The discovery of a new sex chromosome system in a mammal species for
