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Role of the Drosophila Pmi and human TMEM11 proteins in mitochondrial fusion/fission. – Mitopim
La mitochondrie est un organite impliqué dans de nombreux processus essentiels de la cellule. Des résultats démontrent l'impact de la morphogenèse mitochondriale sur de nombreux aspects de la fonction de l'organite tels que la production d'ATP et de ROS. Même si des progrès importants ont été effect
Molecular and biological roles of the imprinted miR-379-miR-410 cluster – ImpMir
miRNAs are endogenously expressed short non-coding RNAs that silence gene expression mostly at the post-transcriptional level. In animals, most miRNAs bind to mRNAs via short, imperfect base-pairing interactions that occur preferentially within the 3’ untranslated regions (UTRs) of target mRNAs. Thr
Role of Stat3/Sosc3 SIgnalling in Modulating the Pathogenesis of Atherosclerosis and vascular Aneurysm – SIMPA
SOCS proteins have emerged as key physiological regulators of both innate and adaptive immunity and control the development of various immuno-inflammatory diseases. SOCS3 is expressed in atherosclerotic lesions and the current paradigm suggests an athero-protective role through inhibition of STAT3 s
Neonatal Fc receptor-mediated tolerance induction in alloimmune and autoimmune conditions – Immunotolerins
Several pathological situations result from a break in immunological tolerance towards endogenous molecules, as seen in autoimmune diseases, or from the inability to mount tolerance towards exogenously administered molecules, as observed in alloimmune responses to protein therapeutics. In this proje
Stem cells and cell therapy for sensori-neural deafness – Stem Cells and Hearing Loss
Sensori-neural hearing loss (SNHL) represents a major public health problem and the most common sensory deficit in humans, affecting 1 in 1000 newborns and a significant portion of the elderly population. In most cases, SNHL is associated with a permanent loss of auditory hair cells (HCs) within the
Dissecting the molecular mechanisms of epithelial architecture and plasticity – ARCHIPLAST
This project aims at deciphering the molecular mechanisms of epithelial stability and remodelling. Epithelia are composed of polarized cells with junctions segregating apical and lateral surfaces. They serve essential functions in separating different physiological environments in the adult. At the
Nuclear siRNA in chromatin dynamics – Nuclear siRNAs
Fifteen to 30 nucleotide-long RNAs lie at the core of a vast silencing network in animals and plants. These small silencing RNAs bind to a member of the Argonaute family of proteins to form RNA-induced silencing complexes (RISC), which they guide to complementary targets. Small RNAs regulate many es
Deciphering the roles of Insulators and co-factors in Nucleosome-Positioning and Nuclear Bodies – INSULa
Cell fate and cell division are processes tightly controlled by the functional and structural organization of the genome intochromatin. Two emerging concepts in chromatin biology are a) nucleosome-positioning, i.e. how the accessibility of the genetic information is controlled through the specific p
Diamond-Blackfan Anemia, a paradigm for ribosomal diseases – RiboCrash
A number of rare genetic diseases have been recently linked to mutations in genes encoding proteins involved in ribosome biogenesis or ribosome function. Most of these pathologies correspond to inherited bone marrow failure syndromes. These recent findings have led to the new concept of ribosomal di
Learning the 3D structure of the proton – 3DLeaP
Protons make up a large part of the visible Universe and yet our understanding of their structure is surprisingly limited. Although Quantum Chromodynamics (QCD) has the potential to explain their emergence in terms of quarks and gluons, it presents us with formidable challenges when it comes to extr
