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Targeting lung epithelial cells or type 3 innate lymphoid cells for the treatment of respiratory infections induced by Klebsiella pneumoniae – TargetInnate
Rationale: Bacterial infections of the lower respiratory tract, i.e. pneumonia represent a major cause of mortality worldwide. The high rate of mortality and morbidity is due to debilitating effects on respiratory functions and the frequent evolution of pneumonia into sepsis, a severe disease with p
Cross-talk between Splicing and RNA Silencing during gene expression – SPLISIL
RNA quality control (RQC) mechanisms eliminate aberrant RNAs, ensuring that only functional mRNAs are effectively translated into proteins. Defects in RQC or saturation by an excess of aberrant RNAs activate siRNA-mediated post-transcriptional silencing (PTGS), which cause the elimination of both ab
Control mechanism of meiotic DSB interference and impact on genome stability – MeioInt
DNA double stand breaks (DSBs) are among the most harmful DNA lesions since a single unrepaired DNA break is enough to trigger cell death. Depending on the cell cycle stage, DSBs can be repaired by non homologous end joining (NHEJ) or by homologous recombination (HR), and dysfunction of any of these
Experimental and numerical toolbox for the development of longer-lasting dental composites – TOOTHBOX
Who is likely to benefit from the results of this project and why? According to the support letters received by the project coordinator (from composite manufacturers, normative institutions, dental education groups …): Everybody! Tooth decay is indeed the most widely spread pathology in the world. D
Rotating Flow and Electroactive Actuators – ETAE
The ETAE project suggests significant advancements about the emergence and control of hydrodynamic instabilities in closed recirculating flows with a free surface. This generic flow configuration is present in numerous industrial contexts. The present aim is, from well-designed excitations by electr
Functional analysis of nuclear reorganisation – FANR
The 3D organisation of the genome has emerged as an important contributor of gene regulation. Misregulation of this organisation is often observed in diseases like cancers. The nuclear periphery is a major landmark of nuclear architecture, directly mediating transcriptional repression. A global nucl
impact of metacognition on behaviour – ImpactMeta
The ability to make good decisions is critical for the survival of individuals or organisations. In this project, we will investigate in particular the role of metacognition in decision making. Metacognition is the ability of agents to assess, evaluate and regulate their own cognitive processes and
Digitalized edition of the AA9 manuscript of the Archives Municipales de Montpellier known as "Le Petit Talamus" – TALAMUS
Beyond the realization of the editon and the restitution both to scholars and to the general public of such an important text, the main objective was to question the relationships established between the town itself and the «Petit Thalamus« which appears to be the changing receptacle of its own memo
GENOmics of PHEnOlogy in the pine processory moth, Thaumetopoea pityocampa – GenoPheno
The main objectives of the project are to identify the genetic bases of phenology in a forest pest insect, the pine processionary moth. This trait is variable and has an adaptive value. We will determine which genomic regions are involved in the control of phenlogy (in terms of date of the sexual re
Governing the Animals – PAN
Our proposal is the crossroads of the sociology of professions and the sociology of public action. It consists in a co-analysis of the evolution of the veterinary profession and the public response mechanisms designed to certify animal health, both in health emergencies situations and in the long ru
