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Restoration of hearing and balance in mouse model for human deafness and balance defects using gene therapy – EARGENCURE
Deafness and balance defects are the most prevalent inherited sensory disorder in humans and is a major concern and a serious burden for Public Health. Today, clinical prevalence of deafness is approximately 1 in 700 newborn. About 80% of deafness cases, associated or note with balance defect, are a
Basic mechanisms balancing plant growth-defense tradeoffs, and influence of global warming – BUGSTER
Plants must grow fast enough to compete with their neighbors, while surviving in the presence of pathogens. Rather than stopping their growth to defend themselves, plants often strike a balance between defense and growth to satisfy simultaneous and yet metabolically conflicting demands. Understandin
Plant-pathogen interaction: impact of small temperature increases and contribution of calcium signaling – CaPPTure
The current global warming scenario predicts an increase of geographic expansion of pathogen distribution and epidemics. These future outbreaks represent a major threat to crops and are likely to cause significant yield losses. In this context, a major challenge is to identify the bases of resistanc
Engineered 3D brown-like adipocytes derived from human iPSCs for in vitro preclinical drug discovery and for cell-based therapy to treat obesity – hiPSC-Adipospheres
Studies on browning of white adipose tissue are limited by the lack of in vitro models mimicking physiological conditions and the native microenvironment. The models conventionally used are mono-cultures, cultured in 2 dimensions (2D), experimental conditions relatively far from the physiological co
Virtual Patient Simulation Tool for Training Health and Social Care Staff Working with People with Alzheimer's Disease or Related dementia – VIRTUALZ
Taking care of the growing population of people with dementia worldwide requires specifically-trained healthcare professionals.Their training should not only involve foundational knowledge but also skills to communicate effectively with people with dementia, cope with care challenges and guarantee p
Cavitation and Confinement – CAVCONF
Cavitation, i.e. the formation of a vapor bubble in a stretched liquid, is of fundamental interest and plays a central role in many technologies and natural science. For decades, the consensus has been that cavitation occurs via the thermally activated formation of a bubble nucleus as described by t
Low-energy excitations in 3D Dirac and Weyl semimetals – DIRAC3D
The DIRAC3D project aimed expanding radically our experimental and theoretical knowledge of emergent 3D Dirac and Weyl semimetals. We searched for their unique response due to three-dimensional massless particles in their Dirac and Weyl nodes as well as due to their characteristic topologically prot
Spin and Valley Dynamics in 2D van der Waals Materials – 2D-vdW-Spin
The physical properties of atomic monolayers are often very different from those of their parent bulk materials. Prime examples are graphene and monolayers of MoS2, as their ultimate thinness makes them extremely promising for applications in electronics and optics. At the same time, they give acces
Biometric fingerprints of trees: log tracing from forest to sawmill and early estimation of wood quality – TreeTrace
The two main objectives of the TreeTrace project were the quality assessment and traceability of logs/bolts based on the analysis of photos of their cross-section taken by sensors such as smartphones or industrial cameras. Traceability is a necessity to combat illegal timber exports, to inform consu
Dynamics of Hippocampo-Cortical Networks in Learning and Memory – DyNet
The ‘two-stage’ theory of memory posits that memory traces initially formed in the hippocampus during the waking state are progressively transferred to the neocortex during sleep, where they are stored and available for long term recall. Candidate target neocortical areas include the medial prefront
