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Indicateurs Biologiques et chImiqueS de Contaminations UrbaineS – IBISCUS
Increasing populations on the shores and the development of industrial and agricultural activities are a priority for monitoring treatment plants, agriculture, and industry waste waters discharge at sea. Pollutants targeted by the project are fecal contamination carried by wastewaters and potential
Photo Dynamic Therapy using photosensitizer-doped targeted organic nanoparticle – TARGET-PDT
Photodynamic therapy (PDT) is an emerging modality for the treatment of various cancers. PDT consists of a photoactive drug known as a photosensitizer, its preferential uptake and retention in malignant tissues, and its subsequent activation by a visible laser light, leading to tumor destruction. De
Biogenèse de la poche flagellaire , caractérisation de l’organelle d’endo-exocytose chez Trypanosoma brucei. – Bio-Pocket
Trypanosoma brucei is a flagellated protozoan parasite that is used as a model organism to study biological phenomena such as gene expression, protein trafficking and cytoskeleton biogenesis. In T. brucei and related parasites endo- and exocytosis occurs exclusively through a specialized, sequestere
Imaging molecular dynamics with attosecond wavepackets – ATTO-WAVE
Tracking the electronic motion in time and space is a main challenge of forthcoming matter science (DOE report 2007). To resolve electron dynamics in matter at the femtosecond time scale or less, attosecond pulses are needed. Since 2001 and first generation of attosecond light pulses, the field has
Targeting melanin-associated disorders mediated by related-dicopper enzymes: from structure/activity relationship to biological applications – 2Cu-TargMelanin
The project is focused on tyrosinase (Ty), a copper-containing metalloenzyme which to date remains poorly characterized. Ty belongs to the type-3 copper-containing enzymes that contain a coupled binuclear active site. Ty is the key enzyme involved in melanins (protective pigments) biosynthesis. It c
Développement de la micromagnétométrie appliquée aux sciences de l'Univers – MagMap
The typical spatial scale for magnetization measurements in paleomagnetism laboratories is 1-10 cm3. This size is indeed perfectly adapted to most "standard" paleomagnetic applications. On the other side, scanning techniques such as Magnetic Force Magnetometry provide very high-resolution magnetic i
Morphométrie cérébrale et variabilité corticale – BrainMorph
Brain morphometry has been an emerging field in the past few years, since the variety of brain data that can be acquired in vivo (in particular with magnetic resonance imaging) has expanded and the computer-assisted techniques necessary to analyze those data have greatly improved. It is now acknowle
An integrative-interactive approach to speech development – VOC2SPEAK
The first two years of life are crucial for speech acquisition from vegetative sounds to babbling to the first words. For decades, empirical studies on infants’ productions have relied on phonetic transcriptions, which have provided crucial insights, yet insufficient information on the underlying a
Computational Aided Engineering Tools for the Design of Thermites-based systems – OASYS
Reactive materials are composites or physical mixtures that demonstrate self-sustaining exothermic reactions upon receiving an initial energy input. This category of materials is distinctive within the realm of energetic materials, differing from explosives in the manner in which reaction fronts pro
Lasers fibrés UV/Moyen-IR: nano-hybridation des technologies photoniques et semiconductrices – QuantumLight
The aim of this proposal is to study original composite fibres in order to develop tuneable laser sources emitting at new wavelengths (especially for the unconventional UV-visible and mid-IR ranges) for applications in information storage, remote sensing of molecules, processing of medical diagnosti
