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Southern Ocean Trophic Changes from Phytoplankton to Upper Predator (SOTroC) – SOTroC
SOTroC investigate how atmospheric-oceanographic conditions influence the orientation of the southern ocean food webs. To do so, SOTroC will determine whether inter-annual variations in atmosphere-ocean forcing conditions translate into the emergence of contrasted food webs within the Southern Ocean
Behavioural Plasticity, Metabolomics and Social Transitions in Spiders – MetaSpi
Sociality is present in all lineages and represents a major evolutionary transition. The maintenance of social cohesion in juveniles at advanced stages is considered the main pathway for the emergence of permanent sociality. Spiders are relevant models for exploring the mechanisms involved in social
Far-from-Equilibrium NaNothermodynamics with Engineered Colored baths – FENNEC
Fascinating phenomena emerge from the appearance of far-from-equilibrium thermodynamic states, from active matter to protein folding dynamics, including non-trivial heat flows. Nevertheless, the complexity of these phenomena makes their fundamental understanding difficult. In this context, the FENNE
Automated Loop-mediated Amplification for Rapid Microalgae Monitoring – ALARMM
Harmful algal blooms (HABs) are sporadic events presenting a serious health risk with economic impact on shellfish and tourism industries. Thus, the detection of toxic microalgae has become a critical challenge, making phytoplankton monitoring with efficient on-field devices essential for the early
Microscopie des Intermédiaires de Réplication et Recombinaison – MIRR
During DNA synthesis, replication fork progression can be compromised by replication fork barriers (RFBs) which can results from various situations (DNA damage, DNA/protein complexes, DNA secondary structures...). Depending on the nature of the replication block, multiple pathways can be employed to
MAss Spectrometry imaging Data Analysis in EYE – MASDA-EYE
By combining the advantages of mass spectrometry (MS) and microscopy in a single experiment, the emerging mass spectrometry imaging (MSI) technology brings extraordinarily powerful capabilities to understand the molecular complexity found in both health and disease. Compared to traditional immunocyt
Régulation du fonctionnement des RCPG : hétéro-oligomérisation et organisation dynamique des récepteurs dans la membrane – GPCR D-I-F
In recent years, the general mechanism of G protein-coupled receptor (GPCR) signaling has been largely revisited, in part because it was shown that a given receptor could form homo- or heteromers with other GPCRs. In addition, the notion that GPCRs must function in the context of a specific multipro
Bases moléculaires de la régulation de l'activité de Deubiquitination des histones – HISTONEDUB
Post-translational modifications of core histone proteins are crucial for transcriptional regulation in eukaryotes. A strong emerging picture is that defects in these cellular mechanisms lead to various diseases, including cancer. Different histone modifications are observed that influence both chro
Causes and consequences of protein aggregation in cellular degeneration – PAGDEG
In this project, we propose interdisciplinary approaches to improve our understanding of cellular degeneration in relation to aging and, in parallel, to antibiotic treatment of Escherichia coli. This bacterium is not only the best-known organism but also the simplest aging model available. We thus
European network on Noonan Syndrome and related disorders – NSEuroNet
A group of disorders caused by dysregulation of the RAS-MAPK signaling pathway has emerged. These rare disorders have overlapping features including reduced growth, facial dysmorphia, cardiac disease, variable cognitive deficits, and predisposition to specific malignancies. While research has provid
