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Bacterial genome wide epistasis: extant, emergence and molecular bases. – GeWiEp
With the analysis of the genomes, it appears that transfers of genetic material within a versatile species like Escherichia coli are frequent and all the more so for the genes involved in antibiotic resistance. However, the resistance problem is mainly associated with a few clones, which suggests th
Bacterial hijacking of nuclear stress responses – SNAPshot
Bacterial effector proteins manipulating host cell functions play a key role in virulence. Our consortium identified sub-nuclear associated proteins (SNAPs) translocated by the stealth bacterial pathogens Brucella abortus and Coxiella burnetii, that localize at promyelocytic leukemia nuclear bodies
Bacterial small regulatory RNAs: how to reconcile target specificity and pleiotropic action – SalsARN
Small non-coding RNAs have emerged as one of the most important classes of regulatory molecules in all living organisms. In bacteria, small RNAs (sRNA) exert their regulatory function by base-pairing with sequences near the translation initiation codon of target messenger RNAs. Most often, formation
Bacterial tyrosine kinases: a new class of enzymes as innovative therapeutic targets – BACTYRKIN
- - - - Protein phosphorylation-dephosphorylation plays a dominant role in signal transduction networks. However, for many years, protein phosphorylation-dephosphorylation was considered a cell's regulatory arsenal that was exclusive to eukaryotes and it was only after a long period of controversy t
Balloon Observations and mOdelling for the Stratosphere - Troposphere Transition in the Tropical Region – BOOST3R
The BOOST3R project made it possible to go beyond the actions carried out in preparation for the Strateole 2 stratospheric balloon campaigns, to develop new instruments and to make progress in our understanding of the equatorial lower stratosphere. The scientific objectives of the project were - to
Bands of Brothers: Institutionalising Fraternal Communities – BOBIFC
This research in Historical International Relations (IR) examines how nations became the dominant political communities shaping the international order. While Benedict Anderson’s concept of the nation as an ‘imagined community’ has been influential, he did not provide a framework for imagination, im
Barrier island hydro-morphodynamics driven by typhoon events – KUN-SHEN
Taiwan is located in a sub-tropical region exposed to extreme meteorological events and is on the track of numerous major typhoons. More than 38 typhoons crossed Taiwan in less than 10 years. Moreover, the South-Western coast of Taiwan displays well-expressed lagoonal systems that do not exist elsew
Basal body anchoring in ciliogenesis: structure-function analysis – ANCHOR
we propose multi-disciplinary approaches, combining biochemical, molecular and cell biology techniques with cryo-electron and STEM tomography. We plan: 1) to identify interacting protein partners involved in the anchoring process using the proximity dependent biotin identification (BioID) technique
Base génétique de la compatibilité naturelle entre les virus de la dengue et leurs moustiques vecteurs – DENGVEC
Emerging arboviral (arthropod-borne viral) diseases among which chikungunya, West Nile and Rift Valley fevers are only the most recent examples represent one of the most serious threats to global public health. Among them, dengue is presently the most prevalent emerging arboviral disease of humans w
Bases moléculaires de la régulation de l'activité de Deubiquitination des histones – HISTONEDUB
Post-translational modifications of core histone proteins are crucial for transcriptional regulation in eukaryotes. A strong emerging picture is that defects in these cellular mechanisms lead to various diseases, including cancer. Different histone modifications are observed that influence both chro
