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Predicting contemporary evolution and population persistence in a changing environment – ContempEvol
Combining experimental and modeling approaches to better understand and predict the eco-evolutionary dynamics observed ‘live’ in nature or in the laboratory, and disentangle their underlying mechanisms, notably the role relative contributions of genetic adaptation and phenotypic plasticity.
Integrative Mobile genetics Elements hijacking the bacterial Chromosome dimer resolution machinery: contribution to the emergence of new pathogenic strains. – IMEX
Bacteria possess a dedicated site-specific recombination machinery, the Xer machinery. Numerous mobile genetic elements hi-jack this machinery to integrate into the genome of their bacterial host. Their presence often correlates with the evolution towards pathogenicity of bacteria. This is notably the case for cholera epidemic strains.
Mechanism of inhibition of a novel target of beta-lactam antibiotics – CarbaTub
Emergence of resistance to multiple antibiotics requires the indentification and chartacterization of new targets for drug developement. The aim of our project is to characterize a promising target for the tretament of multidrug resistant tuberculosis
Archaeological Researches on Metal and Pottery Assemblages from the Oxus Basin to the Indus Valley during Protohistory. – ROXIANA
ROXIANA: the first attempt for analyzing ancient potteries and metal at such a scale in protohistoric Middle Asia.<br />ROXIANA was designed for a better understanding of the development of ancient technologies in Middle Asia, in a time of early urbanization North and South of Hindu Kush (5th-1st millennia BCE).<br />Pottery and metal belong to the «pyrotechnologies« (technologies of fire),a part of craftmanships that were a crucial development on the way of emergence of urban societies in the Old World.<br />
Evo-devo of the diversification and loss of dentition in Birds – PIAFS
Today, no species of bird has teeth. However, most had some at the time of dinosaurs, the Mesozoic. We aim at understanding why and how the avian dentitions have disappeared in the meantime. Then, in the Cenozoic, a now-extinct clade of seabirds, the Odontopterygiformes, evolved jawbones with tooth-like bony outgrowths. Here too, we are investigating the possible modes of development and evolution of these unique and extinct structures.
Revisiting the Population Genetics and Genomics of partially clonal organisms – CLONIX
Adapting population Genetics concepts and methods to partial clonality
Multifunctional molecular probes for fluorescence imaging of cell membranes – Cellmemprobes
Rapidly developing optical imaging techniques require new advanced molecular tools – fluorescent probes. The present project will develop new probes having several functions: specific membrane staining, specific recognition of the membrane proteins (receptors) and color-response to lipid domains in plasma membranes, especially in the nanoscopic surrounding of the receptor.
Modeling and Multi-Scale Simulation of Interfaces – MODEMI
The project aims to:<br />• (i) Carry out direct numerical simulations (DNS) for physical cases with breakup and coalescence<br />• (ii) Establish a comparison and validation of the results obtained by the numerical codes used by partners<br />• (iii) Perform DNS for physical cases involving dispersed media<br />• (iv) Provide models of «sub-grid« to respect the physics of the problem and maintain a quasi-true results of DNS.
Smart-UltraSound: Detection/characterization/control of non-linear ultrasonic sources – Smart US
Smart-UltraSound: Detection/characterization/control of non-linear ultrasonic sources
