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Retinal stem cells activity in neural tissue growth and repair – EYE-STEM
Unlike mammal retina, that of amphibian grows continuously thanks to active retinal stem cells. Besides, such cells are able to contribute to retinal regeneration following lesion in these species. Investigating the molecular mechanisms underlying these processes in the frog could help to set up rational stem-cell-based therapy procedures for human retinal degenerative diseases, such as retinitis pigmentosa or age related macular degeneration.
CXCL12 and tissue regeneration: Mechanisms of action and therapeutic potential – chemrepair
that it plays in embryo and adult life. The exceptional conservation of CXCL12 structure & function in
Crystalline Waveguide for quantum sensors and memories at telecom wavelength – GOMMETTE
r interaction, with the preservation of the exceptional homogeneous linewidths of Er ions. As of now [...] In order to guarantee the conservation of the exceptional properties of Er:YSO, we will develop an original
Water-soluble aza-BODIPY platform for multimodal imaging and trackable therapeutics – WazaBY
Development of a new class of water-soluble fluorophores, optimized for near infrared imaging (NIR).<br />Functionalitzation of the boron center on the aza-BODIPYs, in order to develop new bimodal and theranostic agents.<br />Valorization of the systems by a preclinical study, aiming at the bimodal imaging and theranostic approach of cancers overexpressing PD-L1.
Controlled Computation of Point-Defect Characteristics in High entropy Alloys – CoCoA
This project aims at obtaining an improved understanding of point defect (PDs) physics in High Entropy Alloys (HEAs), and at providing methods to precisely characterize their intrinsic properties at the atomic scale. These quantities are then used to inform meso-scale models (of e.g. mechanical properties and diffusion), so as to predict HEAs behavior and guide alloy design.
Sex chromosome and sex determination evolution in mammals – SEXYMUS
Except a few species, mammals have an extremely conserved sex determining system. However, within the African pygmy mice (genus Mus), we uncovered an extraordinary diversity of sex chromosomes. This diversity and their phylogenetic proximity with the laboratory mouse make them an excellent model. Hence, in the SEXYMUS project, we will investigate the evolution of mammalian sex determination and the evolutionary modification of sex chromosomes using the pygmy mice as proxies.
Deciphering LGI1-related epilepsy using conditional knockouts – LGI1 KO
Mutations of LGI1, which encodes a protein of unknown function, is the cause a familial form of epilepsy. The study of genetically-modified mice reproducing the genetic disease and the phenotype of spontaneous seizures, will guide us toward the comprehension of underlying mechanisms of this disorder.
Protein Glycosylation in pathogenic Gram-positive bacteria – Glyco-path
protein glycosylation in Gram-positive pathogen. Except for S-layers proteins and a new family of serine-rich
Fabrication and advanced caracterizations of all-solid state micro-supercapacitors for pulsed regimes in severe environments – ARTEMIS
FAbrication and advanced caRacterizations of all-solid-state micro-supercapacitors for iMpulsive rEgimes in severe enviRonments
Role of Greb1l in mesoderm patterning and congenital heart defects – PATHPATT_Ukraine
heart malformation, criss-cross heart. Using an exceptional patient cohort, a unique mouse model and cutting-edge
