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The Design of Auctions and Contracts for Renewable Energies: a RISK-sharing perspective – DACRERISK
One of the main economic challenges in the large scale development of renewable energies is how to share risks between public and private entities.
Understanding and preventing the photocatalytic cycle responsible for the occurrence of light-struck flavor in white wines and Champagnes – DeLight
The light-struck fault is now in plain light! Thanks to the De-Light project, we have elucidated the photochemical mechanisms responsible for the formation of the drop of light and proposed technical solutions that can prevent its formation while respecting the constraints linked to the viticultural processes in force.
Mechanisms of membrane rupture and repair: viral assembly strategies. – membrane dynamics
understand the role of both lipids and proteins in the unconventional membrane assembly of large DNA viruses
Identification of Small Molecules Aborting Resistance to TB prodrugs – SMARt-TB
During the last few years, our research-consortium has developed an alternative strategy to revert resistance to antibiotics. We have demonstrated that resistance of M. tb to the prodrug ethionamide can be circumvented by waking up alternative bioactivation pathways using small molecules. <br />Buoyed by this initial success, we have now extended this innovative concept to tackle resistance associated to the two nitroimidazoles: pretomanid and delamanid.
Optimize Anticipation and Decision Making in Extreme Crises to Sustain the Resilience of Society – APRIL
Optimization of anticipation and decision making during extreme crisis situations in order to maintain community resiliency.
Mechanism of interaction of subgroup B2 adenovirus to the desmosomal cadherin DSG2 and applications – Ad-Cadh
In this ANR, we address three major work-packages consisting of (i) the biochemical and biophysical mapping of the domains of interaction between viruses and their receptor, (ii) the resolution of the atomic structure of the complex they form by cryo-EM and X-ray crystallography and (iii) the study of their bio-distribution in mice after modification or not of the natural tropism.
Structure/function study of the respiratory syncytial virus polymerase and search for inhibitors – BRONCHIOLITEASER
Structural and functional studies of the respiratory syncytial virus RNA-dependant RNA polymerase and search for inhibitors
role of INterstitial Solutes and diffusive Processes In the plasticity of Refractory high entropy Alloys – INSPIRA
Refractory High entropy alloys (RHEA) retain excellent mechanical properties at high temperatures, and the role of interstitial solutes can partly explain these properties. However, the complexity of these alloys makes it difficult to understand the underlying physical processes and to optimize the mechanical properties. In this project, we are developping a multi-scale framework to model solid solution strengthening (emerging from substitutional and interstitial solutes) in these alloys.
Algebraic Methods for Cryptography – MAC
difficult (at best sub-exponential) to invert (except if one knows a trapdoor, rendering preimage computation
Retinal stem cells activity in neural tissue growth and repair – EYE-STEM
Unlike mammal retina, that of amphibian grows continuously thanks to active retinal stem cells. Besides, such cells are able to contribute to retinal regeneration following lesion in these species. Investigating the molecular mechanisms underlying these processes in the frog could help to set up rational stem-cell-based therapy procedures for human retinal degenerative diseases, such as retinitis pigmentosa or age related macular degeneration.
