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Vectorization of iridium(III) complexes using siderophore surrogates : a Trojan horse strategy against Gram-negative pathogenic bacteria – VECTRIUM
Resistance to bacterial infections is a major health problem that will increase in the coming decades. The quest for alternatives to conventional antibiotic therapies is therefore necessary. In this context, the use of light to kill bacteria is an emerging strategy. Targeting the bacterial iron uptake pathways will focus the deleterious action of light on pathogens and reducing the impact on the cells of the infected patient.
Unraveling the pathophysiology of Bethlem Myopathy using a unique zebrafish model for the disease – FishandCol6
Bethlem myopathy (BM) is a misunderstood and uncurable disorder characterized by abnormal contractures and muscle weakness. The BM results from mutations in one of the genes encoding the 3 major a-chains of collagen VI (ColVI), a component of the myomatrix, but the mechanisms of action have not been elucidated. Our working hypothesis is that muscle dysfunction caused by BM mutation results from alteration in muscle excitation and/or intracellular Ca2+ homeostasis.
