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FLT3 inhibitors for the treatment of neuropathic pain – NEUROPATH
Neuropathic pain (NP) is a chronic pain disorder caused by nerve damage secondary to other pathologies (eg diabetes), or surgical or traumatic lesions. Treatments for NP are non-specific, inefficient and generate side effects. NEUROPATH researchers found that NP was selectively initiated and maintained by stimulation of the Tyrosine Kinase Receptor FLT3, which therefore appears to be a relevant therapeutic target for NP.
"Hurricanes 2017" - Disaster, Risk and Resilience
with events which magnitude and frequency are exceptional. For any information or guidance
Sensemaking and Spatialisation for multi-granular heritage artefacts : 3D annotations, sonification. and formalisation of inferences – SESAMES
Sensemaking and Spatialisation for multi-granular heritage artefacts: 3D annotations, sonification. and formalisation of inferences
Biohydrogen production: towards an innovative added-value bioprocess in anaerobic digestion-based waste treatment plant – ProBHyM
Biohydrogen production: towards an innovative added-value bioprocess in anaerobic digestion-based waste treatment plant
How Domain-general Functions Contribute to the Development of Numerical Competencies – DFCDNC
inhibition factor or correlated with each other, except for a small positive correlation observed between
The Design of Auctions and Contracts for Renewable Energies: a RISK-sharing perspective – DACRERISK
One of the main economic challenges in the large scale development of renewable energies is how to share risks between public and private entities.
Identification of Small Molecules Aborting Resistance to TB prodrugs – SMARt-TB
During the last few years, our research-consortium has developed an alternative strategy to revert resistance to antibiotics. We have demonstrated that resistance of M. tb to the prodrug ethionamide can be circumvented by waking up alternative bioactivation pathways using small molecules. <br />Buoyed by this initial success, we have now extended this innovative concept to tackle resistance associated to the two nitroimidazoles: pretomanid and delamanid.
Optimize Anticipation and Decision Making in Extreme Crises to Sustain the Resilience of Society – APRIL
Optimization of anticipation and decision making during extreme crisis situations in order to maintain community resiliency.
Mechanism of interaction of subgroup B2 adenovirus to the desmosomal cadherin DSG2 and applications – Ad-Cadh
In this ANR, we address three major work-packages consisting of (i) the biochemical and biophysical mapping of the domains of interaction between viruses and their receptor, (ii) the resolution of the atomic structure of the complex they form by cryo-EM and X-ray crystallography and (iii) the study of their bio-distribution in mice after modification or not of the natural tropism.
ERA-NET on Cardiovascular Diseases Joint Transnational Call for Proposals 2018 (JTC 2018): “Transnational Cardiovascular Research Projects driven by Early career scientists”
call will be accepted per application. As an exception, two (2) research groups from Spain may be comprised
