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Optimization methods for the integrated study of complex decisional problems – ATHENA
Optimization methods for solving difficult integrated decision problems
How the balance of excitation and inhibition shapes orientation selectivity and center-surround interactions in superficial layers in area V1: a combined experimental and modeling project – BalaV1
The activity of neurons in the primary visual cortex (V1) displays a very high level of synaptic «noise«. But is it really «noise«? Theoretical studies indicated that the «noise« is the result of the strong interactions - excitatory and inhibitory – taking place between neurons. These interactions must be balanced (so-called «balanced« state) for maintaining the activity level in a reasonable range. Our aim is to study the role of this emerging noise in the genesis of the responses in area V1.
AFTER the end: reassembly of marine communities during the Early Triassic recovery – AFTER
The core idea of this project comes from recent discoveries on the PT crisis and its recovery by our team. These significant advances markedly<br />contrast with the classic, world-wide “delayed recovery” scenario and its associated paradigms.Our main goal is thus to test the “delayed recovery” model at a local to regional (i.e. ecologically functional) scale, looking for the potential drivers that influenced patterns and processes of the biotic recovery.
Frontier Research in Radical Initiating Systems: PhotoRedox Catalysis as a new strategy for polymer synthesis – PHOTOREDOX
The PHOTOREDOX project presented here consists in developing new photoinitiators built on a new concept: the CATALYSIS PHOTOREDOX.<br /><br />By the mobilized skills and by its finalized shutter, the Photoredox project will contribute to the preservation of an activity and ambitious research in the sector of the chemistry of the processes under light irradiation . The French research (academic or industrial) occupies in this particular domain a recognized place at the international level).
Lanthanide complexes as Trojan Horse for proteins structural studies – Ln23
The Ln23 project proposes to exploit lanthanide complexes noted [Ln], as Trojan Horses for structural determination of proteins by developing original and straightforward methodologies for three complementary structural techniques, namely X-ray crystallography including crystallogenesis, Small-Angle X-ray Scattering (SAXS) and solid-state NMR. Ultimately, the dissemination of these new integrative tool in the structural biology community.
Covalent crystalline organosilica networks – CrystOS
Self-organized organosilicas: Synthesis under thermodynamic control or by assembly of elementary bricks; Stable thin films for OFET.
Multiscale Operando Structural chAracterization of vanadium phosphate Industrial Catalysts – MOSAIC
A fundamental work is dedicated to the global and local structural order characterization of the different phases present in the industrial catalyst. We would like to elucidate the probable dynamic effects which may be present in different phases constitutive of the active catalyst and influence the reactivity of the material in the operating conditions. For that purpose, a combination of multiscale X-ray scattering experiments and solid state NMR analysis in Operando conditions is developed.
Next steps in Synthetic Biology: towards the generalization of genome transplantation methods – SYNBIOMOLL
SYNBIOMOLL aims at extending Synthetic Biology key technologies to Mollicutes species of interest. Because several bacterial genomes have already been cloned in yeast and the synthetic assembly of large DNA fragments is in current use, the major technological limitation is our ability to extend the genome transplantation technology to other microbial species. This project could therefore lead to a better comprehension of the biology of pathogenic bacteria and the development of new vaccines.
Bisubstrate and prodrug approaches for the rational design of new DXR nhibitors: Novel antimicrobial and antitubercular drugs – ANTITUB
Today, almost all important microbial infections throughout the world, such as tuberculosis, malaria, nosocomial diseases, are becoming resistant to antibiotics. Antimicrobial multi-drug resistance has been called one of the world's most pressing public health problems. It is therefore urgent to find innovative targets for new antimicrobial drugs.
