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Early detection and prevention of cardiac dysfunction and heart failure induced by cancer chemotherapeutics
Cardiac dysfunction leading to heart failure can result from anticancer drug-induced cardiotoxicity. It is the second cause of morbidity and mortality among cancer survivors, a group that is growing
The impact of gestational diabetes mellitus (GDM) upon the epigenetics of mother and newborn infant and long-term risk of type 2 diabetes – Epi-GDM
Gestational diabetes mellitus (GDM) is a form of diabetes that is first diagnosed during pregnancy and poses an important risk factor to the subsequent health of the mother and her developing child. A
Auditory space and multisensory attention in cochlear implant patients – VIRTUALHEARING3D
Cochlear implants CI are electronic devices that provide partial hearing to individuals who are profoundly deaf or severely hard-of-hearing. They substitute the damaged receptors of the cochlea, trans
MItral Valve Disease: From Genetics to Mechanisms and Improved CARE – I-CARE
Mitral valve prolapse (MVP) is a common cardiac valve disease. It can manifest as mitral regurgitation and is the leading indication for mitral valve surgery. Despite a clear heritable component, the
TARGETING ACTIVATED MINERALOCORTICOID RECEPTOR IN PULMONARY ARTERIAL HYPERTENSION: A translational approach towards treatment – TAMIRAH
Pulmonary Arterial Hypertension (PAH) is a frequently lethal condition without cure. The current therapies remain essentially palliative and do not reverse the progressive pulmonary vascular obstructi
Silencing excitability of epileptogenic networks in Early Epileptic Disorders – SILENCEED
Cortical malformations are the most frequent causes of drug-resistant childhood epilepsies carrying a lifelong perspective of disability and reduced quality of life. Treatment options for pediatric ep
Impact of the modulation of Soluble epoxide hydrolase enzymatic Activities on Pulmonary HypertensIon and Right ventricular dysfunction in experimental and human heart failure – SAPHIR
Despite major therapeutic advances, the worsening heart failure (HF) epidemic and the associated healthcare costs represent a major burden to public health and the healthcare system. This is notably r
Imaging SLCO Transport function in clearance and non-clearance Organs in Human: implication for drug PharmacoKinetics and tissue disposition variability – ISOTOPK
In Human, the fate of drugs in the body is estimated thanks to clinical pharmacokinetics (PK) through the determination of its concentrations in plasma. Clinically relevant gender and age-related diff
Investigation of in vivo human type I interferon production and control in the type I interferonopathies – IFNX
Type I interferons (IFNs) have long been recognised as key immune mediators, in particular in anti-viral defence. Due to their potent and broad effect the IFN response operates along a spectrum, and m
Translational investigation of the pathophysiological role of intestinal barrier dysfunction and microbiota in juvenile idiopathic arthritis – GUT-JIA
Translational investigation of the pathophysiological role of intestinal barrier dysfunction and microbiota in juvenile idiopathic arthritis Juvenile idiopathic arthritis (JIA) is the most common c
