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Basic Technological Research – RTB+ (ANR-09-RTBP-0002)
In 2003, the French Ministry of Research expressed the need for a national initiative in nanosciences and nanotechnologies in order to increase the competitiveness of the national research community i
Basic Technological Research – RTB+ (ANR-09-RTBP-0001)
In 2003, the French Ministry of Research expressed the need for a national initiative in nanosciences and nanotechnologies in order to increase the competitiveness of the national research community i
Conception, synthèse et études métaboliques de nouveaux pièges pour la détection de radicaux libres dans les systèmes biologiques – SPIN BioRad
Developments in the spin trapping / EPR technique for the detection and the characterization of free radicals in biological systems.
Nouvelles stratégies de marquage paramagnétique pour l’étude des transitions structurales dans les protéines désordonnées – SPINFOLD
Development of new paramagnetic probes to determine by EPR spectroscopy the dynamic and structural properties of disordered<br />proteins at nanometric scale. Thanks to the diversification of the grafting sites and of the spectroscopic signatures brought by these new probes, it is now possible to develop Biostructural EPR methods well adapted to<br />the study of flexible proteins and of large size biological systems.
Le rôle des ions métalliques dans l'agregation, la production de radicaux et la toxicité du peptide amyloïde-? – Neurometals
It was shown that copper and zinc ions play a key role in the aggregation of A? peptides and neuronal toxicity. The purpose of this project was to understand the role of copper and zinc ions in the two key stages of AD development as well as the molecular mechanisms they are associated
Synthèse de nouveaux nitroxides pour le diagnostic et l'étude de pathologie chez le petit animal via l'activité des protéases vue par IRM et effet Overhauser. – NITROMRI
No non-invasive spectroscopic techniques as efficient as MRI and suitable to monitor the enzymatic activity in tumors are available. This project aims to develop a new technique of MRI: the Overhauser-enhaced MRI which amplifies the conventional signal and is suitable for investigating in vivo the enzymatic activity.