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Adult skeletal muscle stem cell regulation by Bone morphogenetic protein signaling – BMP-MYOSTEM
Adult skeletal muscle possesses the ability to fully regenerate and this depends on the presence of quiescent muscle stem cells, so-called satellite cells that lie in juxtaposition with each myofiber
Role of alternative macrophages in vascular calcification – AlMaVasCal
The ectopic deposition of calcium within the atherosclerotic plaques leads to the development of vascular calcification (VC), a complication for atherosclerosis disease. VC is a dynamic process that t
Investigating the role of phosphoinositides during plant cytokinesis – INTERPLAY
Cytokinesis is the final step of cell division, partitioning the cytoplasm between the daughter cells. In animal cells, this event is driven by cortical contraction that squeezes the cell into two and
Physical and molecular determinants for the allometric control of spindle size – CytoScale
During metazoan development, embryonic cells decrease in size by up to two orders of magnitude (from 1.2 mm to 12 µm in Xenopus laevis) as a consequence of multiple rounds of cell division without gro
Intermediate filaments: from single filament to dynamic network – SiFi2Net
Organization and dynamics are essential for IF to perform their functions in cells. Defects in IF organization caused by point mutations lead to many human pathologies. Here we propose to combine cellular, biochemical and biophysical methods with cutting-edge microscopy techniques and theoretical modeling to draw a clear picture of the IF dynamical properties (assembly/disassembly, transport, reorganization).
Role of the Planar Cell Polarity (PCP) signaling in the dynamic organization of synapses and the integration of synaptic information: from basic mechanisms to patho-physiological consequences – NanoPlanSYN
Our goal is to decipher the spatiotemporal mechanisms controlled by the planar cell polarity (PCP) signaling in spine during specification and morpho-fonctional plasticity that depend on the dynamics
Cellular Plasticity in ageing – iCELLPLASTICITY
Ageing has long been recognized as a major risk factor for many diseases as it associates with dramatically increased chronic diseases, including cancer, diabetes, and neurodegenerative diseases. An e
Cell migration in gut homeostasis – HOMEOGUT
The epithelium of the small intestine is composed of a single layer of cells that line the villi that project into the lumen of the gut, and the crypts that descend into the underlying connective tiss
Size-control of the hair-cell bundle for frequency-selective auditory detection – HAIRBUNDLEMORPH
Our ability to communicate with speech or enjoy music relies on acute frequency discrimination over a broad range of sound frequencies. To cope with this requirement, the auditory sensory organ of th
Regulation of growth and morphogenesis by gibberellins at the shoot apex – GrowthDynamics
Understanding the molecular mechanisms underlying the construction of multicellular organisms is a central question in biology that can yield key knowledge with a wide range of potential applications
