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Interactions between chromatin and the transcriptional co-activators TFIID, ATAC and SAGA – ChromAct
This project aims at studying the fundamental mechanisms that drive eukaryotic gene expression at the level of transcription initiation . Our bjective is to understand how protein nanomachines contribute to gene expression and its regulation
3D polyelectrolyte scaffolds for prostatic cell culture : a tool to study the influence of the microenvironment on cancerous phenotype and to identify new biomarkers – BROCOLI
a tool to study the influence of the microenvironment<br />on cancerous phenotype and to identify new<br />biomarkers
Auxin-dependent dynamics of cell wall xyloglucans – AuxiWall
In this project we want to identifiy the actors of biosynthesis and remodeling of Xyloglucan that are controled by the Auxin and how does this fine tuning of cell wall structure does impact physical properties of the cell wall and consequently the cell elongation.
Single-molecule microscopy of blocked replication forks – MicroRep
The use of a microscopy technique for the observation of single fluorescent molecules in living bacteria will allow us to understand how a living organism deals with replication impediment and why replication impairment is linked in all organisms to chromosome breakage and genomic rearrangements.
Function of RNaseIII-like proteins in plants. Implication in the epigenome. – Epi-RNase
Small RNas are produced by RNaseIII proteins of the Dicer type and regulate gene expression during development and in response to stresses. most organisms also possess classical RNaseIII proteins which function mostly remain unknown. The aim of this project is to study these proteins using the plant model species Arabidopsis
Impact of DNA methylation on meiotic recombination in Arabidopsis thaliana – MeioMeth
Factors that control the position and the rates of meiotic recombination events are poorly understood but suggest the presence in various species of an underlying epigenetic control. We are going to test if DNa methylation is involved in this control.
Androgen target genes in nervous system: an approach to study sex bias in neurodevelopmental diseases – HARTaGeNe (Human AR Target Genes in Neur
Can the effect of androgen exposition on the expression of key genes during brain development be the cause of the excess of boys affected by autism and intellectual disability?
Plant manganese nutrition for optimal photosynthesis and growth – PlantMan
The project aims at understanding the mechanisms that enable plant to capture manganese, an essential nutrient, from soils and bring it to the photosynthetic centers where it plays a critical role in producing dioxygen from water and convert solar energy to chemical energy for the cell.
Chloroplast And Starch DIVision Analysis : identification of the molecular cross talk – CaSta DivA
Starch is a polysaccharide present in our day life for food and non-food applications. Understanding the molecular mechanisms use by plants to control its synthesis is challenging in a society that must ensure the subsistence of 7 billions of humans.
Generation of mice with targeted mutation of the mitochondrial DNA – Mito-Mouse
Mitochondrial diseases are associated to nuclear mutations and by mitochondrial DNA mutations. To date, no animal model of a mitochondrial disease is available to study pathologies associated to mtDNA mutations.