Search

The primary goal of this project is to enable parallel three-dimensional (3D) activation of neurons via the use of optogenetic approaches and light-patterning methods used for the generation of extended laser patterns that illuminate neurons’ surface simultaneously. We use Computer-Generated Hologra

The SYNCHRO-TC project is fully involved in the evolution of the health sector with distance-based medical care and information sites or services surrounding health. The issues are part of a social and economic context. The main issue is to improve mental functioning of the TBI patient and its qua

The main objective of the PIEZOBIO project is to study and develop the use of piezoelectric materials for the generation of cold plasma discharges for the decontamination of medical equipment. This method of generation, if it proved to be efficient, would make it possible to avoid high-voltage power

CONTEXT:Health Big Data (HBD) is radically changing the way researchers relate to information for medical research. HBD can be exploited at different levels and across different domains, especially for multidisciplinary research. The secondary use of HBD is a promising step towards decreasing resear

The scientific aim of the Diabeloop_AP project is to develop a model of type 1 diabetes that takes into account physical activity and emotional stress in addition to insulin infusion and interstitial glucose levels in order to optimize therapy and bioregulation of subjects’ blood glucose levels. Thi

The project objective is to develop coatings based on multisubstituted nanostructured calcium phosphates with an adjusted morphology, excellent short and long terms biocompatibility, very good adhesion on prosthetic materials and bactericidal properties. The project therefore aims at : i) assessing

We propose to take advantage of the fluidics of the bloodstream, in vivo, to capture these cellular biomarkers with improved sensitivity and response time and with no sampling bias. To that purpose we will i) integrate simulation and in vitro experimentation in the design and evaluation of an intrav

Sodium (23Na) MRI provides a unique and non-invasive way to detect and quantify in vivo sodium concentrations. Pathological studies have evidenced that mitochondrial dysfunction results in intra-axonal sodium accumulation leading to neuronal injury, responsible for irreversible disability. To date,

Red blood cells (RBCs) in normal blood flowing through human vessels constitute reversible aggregates. Aggregates usually form rouleaux or complex three-dimensional structures. The aggregation phenomenon is normal and occurs in the circulation of many mammalian species. However, hyperaggregation is

The objective of SATURN is the development of simulation tools dedicated to High Intensity Therapeutic Ultrasound. The project is based on the creation of a simulation platform from which will be developed software tools dedicated to targeted industrial applications: Simulation module used in the l

The overall aim of INI is to overcome the fundamental hurdle of the blood-cochlear barrier and to allow opening up new horizons for novel therapeutic strategies using innovative medical implants and intratympanic gels to treat ear ailments. Specific objectives include: - Development of liposome-

Technological innovation in the field of biomaterials plays a major role in improving the performance and biocompatibility of surgical implants, and opens new therapeutic perspectives. In this context, MIMATIC is a transversal research program that aims to develop a new class of biomaterials and bio

Invasive biopsy is still today the reference diagnostic technique of a lot of skin pathologies (inflammation, tumors). Nevertheless, several situations of diagnosis should be kept as conservative as possible. Consequently, non-invasive imaging methods (ultrasounds, computed tomography, magnetic reso

The FLAPS-MONITORING project aims at providing a technological solution to monitor the oxygenation of deep tissues. This is achieved with an optical laser probe capable of measuring the amount of blood present in the tissue, and to determine its oxygenation level (ratio oxyhemoglobin / de-oxyhemoglo

Our objective is to design in this three-year project an original “lab-on-fiber” tool for remote, label-free “in vivo” molecular analysis that could be dedicated in the future to endoscopic diagnosis. While micro-arrays are currently used “in vitro” for multi-parametric detections of biomarkers, con

If a fully sampled matrix probe with high channel count approach remains the gold standard technique for 3D imaging in research and ultrafast 4D ultrasound imaging, it however, has several limitations for clinical applications: - The full 2D matrix array and the 1024 channels scanner are expensive

It is now commonly admitted that the combination of focused ultrasound and microbubbles could temporarily deforms endothelial cells and change the integration of tight junctions, leading to the temporarily disruption of the blood brain barrier (BBB) and thereby increases the efficiency of drug deliv

The LBSMI project aims at developing a workflow starting from medical images and resulting in patient-specific soft tissue simulations. Such workflow does not exist at this moment, because current numerical methods employed in biomechanics such as Finite Element Method need a geometrical model that

Image-guided radiotherapy (IGRT) and adaptive radiotherapy (ART) represents an indispensable, life-saving therapeutic approach against cancer, in the frame of predictive medicine. IGRT/ART treatment scenarios required multiple imaging sessions to define accurately the target volume and to monitor th

The major reason for the high rate of rejection of myoelectric prostheses after upper arm amputation is the unnatural control of the hand and wrist functions as well as the limited number of degrees of freedom (DoF) of the prosthesis. No solution has ever been proposed based on the natural neuromusc

Primary liver cancer, including hepatocellular carcinoma (CHC) is the sixth most common cancer in the world with rising incidence. Early and accurate diagnosis is essential for proper management of cancer and patient survival. Diagnostic criteria mainly rely on updated AASLD and EASL imaging guideli

Dysfunctions of the central nervous system are a major economic and social issue. Neural prostheses and brain-computer interfaces offer promising perspectives to restore motor functions and communication capabilities in patients suffering from severe paralysis. These approaches require the implantat

The current improvement in life expectancy, thanks to medical and technical progress, results in an increase in the elderly population. However, life expectancy without disability has not followed the same curve, due to an increase in the prevalence of chronic conditions or diseases related to aging

Current techniques of observation of myelin in vivo in the spinal cord axonal network, such as Magnetic resonance imaging and Positron emission tomography (PET), are limited in their specificity to myelin, and in their spatial scale resolution, which is not compatible with single cell scale observat

In the last decade, cellular and systems neuroscience have experienced a thorough paradigmatic shift following the optogenetic revolution. Optogenetics provides the capability to record and modify the activity of genetically defined cell types in the brain, through light-activated protein-encoded re

The SuperQIF project aims at initiating the development of a low-field MRI system which is intended to be inexpensive, open-spaced for both patients and physicians, and more equitably spread across the territory. To do so, it is proposed to transfer a new class of ultra-sensitive detectors in low-fi