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Ambiphilic ligands enable the introduction of Lewis acids nearby transition metals and thereby open the route to completely new catalytic approaches involving intramolecular Lewis acid assistance. In this perspective, the COLAMET project aims at identifying and understanding how and under which cond

The objective of PeroxiDiv was to explore the diversity of these biocatalysts through different approaches. On the one hand, datamining of recently sequenced fungal genomes. On the other hand, the development and implementation of an environmental genomics strategy that allows the capture and charac

-Superoxide dismutase (SODs) are metalloenzymes involved in cellular protection against oxidative stress. Their catalytic activity of superoxide dismutation can be reproduced by low molecular weight Mn complexes, called SOD mimes (SODm). The general characteristics of SODs (redox potential, electros

The scientific challenges of EPOX are the following: • Develop nanostructured electrochemically promoted Ag-based catalysts coupling high specific surface area and electronic conductivity. • Investigate and understand the mechanism of the electrochemical promotion of ethylene epoxidation to highli

Oxidation reactions are key transformations in organic chemistry because they can increase chemical complexity and incorporate heteroatoms substituents into carbon-based molecules. This principle is manifested in the conversion of petrochemical feedstocks into commodity chemicals and in the synthesi

Catalytic dehydrogenative hydrofunctionalization is a simple way to synthesize organic molecules bearing a vinyl fragment. We want to synthesize, via a dehydrogenative hydroboration or hydrosilylation process with ethylene, ethenylboranes and ethenylsilanes, respectively. The resulting products are

The project DYNAMISTE fundamental research and aims at developing experimental and theoretical tools in order to optimise the industrial processes in which alkali activation solutions of aluminosilicates are involved such as liquefaction of ceramics, binders for mineral paints, refractory mortars or

The «CHADOC« project aims to develop new chiral, robust and selective catalysts for the direct functionalization of C-H bonds. The first objective of this project is the synthesis and the complete characterization of new metal complexes of transitions incorporating the recently developed N-heterocy

Novel catalysts and eco-efficient processes are required to use alternative feedstock such as biomass-derived poly-alcohols. Several challenges have to be faced during the development of those catalysts. Firstly, cheap and abundant metals should replace noble metals or toxic ones. Secondly, for obvi

Glycoconjugates are key molecules involved in many biological phenomena and more particularly in cellular communication and molecular recognition through their saccharidic part. Their natural occurrence and relevant biological role contributed to the strong emergence of glycosciences in the last 20

The PICPOSS proposal seeks to develop a continuous flow process for the sustainable production of fine chemicals and pharmaceuticals through sensitized photo-oxygenations. The specific research aims are: • to use LED-driven microreactors as an energy-efficient and safe technology that increases yie

Cerebrovascular stroke or trauma lead to an important loss of neuronal tissue, leading to strong disability. A current challenge in the field of tissue engineering is to make implants that first ensure a good survival of implanted neuronal cells. A greater challenge is also to direct the growth of t

The drive to miniaturize devices has led to a variety of molecular machines inspired by their macroscopic counterparts such as molecular motors, switches, nanovehicles and tweezers. Even if the control of motion at the molecular level has been mastered by some machines, the reversible control of pro

The MESOPIC project will develop a new path to multifunctional mesoporous materials, which limits the number of steps and allows recycling of the templates. It relies on the design of micellar structuring agents reversibly assembled by electrostatic complexation (Poly Ions Complexation) of double-h

Disulfide-rich peptides (DRPs) form an incredibly diverse group of bioactive natural products (millions of sequences). These constrained polycyclic peptides are composed of 10 to 90 amino acids (aa) of which more than 10% of cysteines are involved in disulfide bridges. Many of these miniproteins hav

In MULTIPLET we develop well targeted molecular assemblies consisting of molecular catalysts based on Mn or Fe complexes and a photoactive chromophore. For this purpose we take profit of a versatile synthetic route based on click chemistry. Performing OATR from water to an organic substrate, we exp

Given the fast growing importance of long polypeptides or proteins in the drug market, the development of processes enabling the efficient total synthesis of cyclic analog libraries is of utmost importance. The aim of this project is to develop an innovative self-purifying process enabling the synth

At the forefront of the rising fields of Chemical and Synthetic Biology, CarbUniVax is a multidisciplinary project sitting at the frontier between Glycosciences and Vaccinology. The ambition of the project is to propose new highly convergent chemical and chemo-enzymatic routes to deliver fine-tuned

The project H2CAT aims at synthesizing 100% agro-based resins with applicative properties. This includes the synthesis of new monomers derived from bio-butadiene and polyols via etherification reactions. - The project has allowed the synthesis of glycerol ethers at 200 g scale. For this purpose, 1L

The depletion of the fossil reserves and the global warming concern have boosted researches on the utilization of biomass as renewable raw material. Lignocellulosic biomass is mainly composed by 75% of carbohydrates along with lignin. Hence, many researches are devoted to the conversion of carbohydr

The purpose of PolarOBC (Polar Olefin Block Copolymers) project is to answer simultaneously two major challenges in the field of polyolefins, the most industrially produced polymers: the control of the synthesis of block copolymers and the introduction of polar functions. Improvment of the control o

The objective of the ANR project CaFeCAT is to study oxygen-deficient perovskites, in particular Brownmillerite type oxides, as active catalyst supports. Brownmillerites and oxygen-deficient perovskites are known for their oxygen mobility at low temperature and are potentially able to act as oxygen

Catalytic processes form the fundamentals of modern chemical and pharmaceutical industries. In the developed industrial countries catalytic processes create about 20% of the Gross Domestic Product (GDP) making production of catalysts a strategic importance for the country economy. Chemical catalysts

There are relevant opportunities to develop innovative synthetic strategies at the frontier between biotechnology and traditional organic chemistry to produce polymers fulfilling requirements of sustainability and precision, towards the development of functional, high value-added, polymer materials

The decrease in non-renewable natural resources has become a global concern for the future, and it is usually the main issue associated with fossil fuel feedstock. However, precious transition metals, which are extensively used for catalytic processes in the chemical industry are also limited, and t

Acylated amino acids or peptides are increasingly used, mainly as biosurfactants in ecologically friendly cleaning products, cosmetic and pharmaceuticals. The global biosurfactants market should rise by approximately 27% till 2018 with an increasing competition between industrial leaders. Acylated a

Petroleum resources currently provide the main raw material used in the production of chemicals including synthetic polymers. In addition to the escalating scarcity of these resources, the harmful impact on human health as well as on environment is motivating the scientific community to develop sust

Protein-Protein interactions (PPIs) are critically involved in numerous biological events. They are also associated with a number of pathological situations, and thus represent important therapeutic targets. Inhibiting PPIs is challenging in part because of the difficulty to target the extended surf