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Genetic Dating in the Post-Genomic Era – DATGEN
The advent of high-throughput genotyping technologies has revolutionized evolutionary biology and genetics. These fields are now inundated by massive quantities of data, as determining dense sets of genotypes from individual genomes is no longer an overly expensive and difficult task. In the next fe
Computational methods for the analysis of transcriptional regulation in Plasmodium falciparum – PlasmoExpress
Malaria is one of the deadliest infectious diseases, threatening half a billion humans worldwide with a yearly death toll of 1 to 2 million people, mainly in developing countries. Malaria is due to infections by protozoan parasites of the Plasmodium genus, transmitted by bites of female Anophel
Sex chromosome and sex determination evolution in mammals – SEXYMUS
The project SEXYMUS will focus on different aspects of sex chromosome evolution The research program is organized into three main questions: - How do new sex determining systems evolve and what are their genic characteristics? The discovery of a new sex chromosome system in a mammal species for
Epigenetic silencing by small ovarian RNAs – ESSOR
Transposable elements (TEs) are DNA sequences able to move around the genome. Their random insertion could interfere with the regulation of gene expression in the cells and could induce important cellular deregulations. Their transposition frequency is maintained at a very low level especially in th
STRUCTURE, DYNAMICS AND EVOLUTION OF THE GENETIC NETWORKS DRIVING YEAST ADAPTATION TO THE ENVIRONMENT – STRUDYEV
Living cells are complex systems made of thousands of genes whose products are involved in a dynamic network of functional interactions. The amazing advances in molecular genomics allow us to deal with this complexity. It is now possible to measure the expression of the whole genome in a single expe
"Bivalent Chromatin and cell fate determination" – BIVANDEV
Changes in gene expression are caused by sequence-specific transcription factors but are also accompanied or caused by epigenetic factors. These factors, by chemically modifying the chomatin (i.e: DNA + associated proteins- the histones) directly influence gene expression, toward activation or repre
Epigenetics and post-translational control of gene expression at the chomatin level – CHROMAPKA
Our objective is to contribute, by proteomics and phosphoproteomics approaches, to the understanding of the molecular mechanisms occurring in time and space at the chromatin level to control gene expression. We wish to reconstitute which proteins shuttle to or from the chromatin and which get dynami
Perception of lipo-chitooligosaccharides and roles of their putative receptors in non legumes – LCOinNONLEGUMES
Lipo-chitooligosaccharides (LCOs) are chemical molecules secreted by symbiotic bacteria called rhizobia. These LCOs are essential for the establishment of the nitrogen-fixing symbiosis between rhizobia and roots of plants belonging to the legume family. Recently it has been shown that LCOs are also