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Resource-problem-free catalyst: low-valent silicon(II) complexes – NOPROBLEM
Transition-metal catalysts with a versatile coordination mode and reactivity, allowing highly efficient and selective reactions under mild conditions, are indispensable in actual organic synthesis. However, in spite of the significant importance of organometallic catalysts, the principal problem is
Supramolecular redox control of a biomimetic metallo-site (Cu) embedded in a cavity – cavity-zyme(Cu)
Widen the field of exploitation of the cavity-zyme concept: new ligands, new caps, new platforms, new cavities, maintaining the possible comparison with the classical ligands, and thus biomimetic systems (organic and inorganic synthesis, spectroscopy, electrochemistry…). - Reactivity with O2: preli
Solid-state NMR methods for protein and protein complexes. – Bio-ssNMR
A complex network of protein-protein interactions controls chemistry inside living cells. The knowledge of the molecular structure of a protein provides key information to understand the relationships between its sequence, its function and disease. A comprehensive portrait of cell biochemistry must
Light-Driven Single-Molecule Magnetic Switch – SWITCH
One of the main challenges of advanced chemistry is undoubtedly the use of single molecules to fulfil specific functions under a remote control. In this context of nanoscience, our research proposal is aimed at designing, synthesizing, studying and finally addressing prototypical photoswitchable sin
Organometallic Mediated Radical Polymerization – OMRP
This project has four scientific objectives: (1) extend the utility of organometallic mediated radical polymerization to control the chain growth of less reactive monomers such as alpha-olefins and vinyl ethers; (2) develop a general understanding of the criteria that favour a reversible radical tra
Unusual metal / ligand interactions supported by donor buttresses – MeLiBo
Thanks to the progress achieved over the last few years with group 13 (B, Al, Ga…) and group 14 (Si, Sn) elements, the ability of Lewis acids to coordinate as Z-type ligands (two-electron sigma-acceptors) to transition metals appears much more general than believed initially. This concept opens very
New chemistries of SIALIc acid targeting the FLU virus – SIALIFLU
- Discovery of new selective ligands of neuraminidases 1 from type A Influenza, targeting both the catalytic site and the “150 loop” cavity, the last one being recently evidenced in the proximity of the main binding site of the enzyme. -Preparation of neuraminidase inhibitors with a dihydropyran
Postranscriptional modification of transfer RNAs via radical insertion. – INSERAD
Most RNA molecules comprise modified nucleosides throughout their primary structure. To date, more than 100 chemically distinct nucleosides have been identified, spanning a wide range of chemical complexity. tRNAs are by far the nucleic acids that are the most frequently and diversely modified by sp
New fluorophores for LifeSciences – PROFLUO
pProteomics is the study and identification of all the proteins (the proteome) present in a biological environment (organism, organ, tissue, cell...). This is a major challenge as composition in proteins can vary as a function of time, environment and condition of the studied organism. Proteins are
Structural characterization of highly specific membrane protein-lipid interactions involved in trafficking. A novel regulatory mechanism in membrane dynamics? – ProLipIn
The sorting of proteins and lipids between different organelles is a key requirement for the proper functioning of cells. Membrane traffic involves the shuttling of specialized (COPI) vesicles between the ER and the Golgi and a number of proteins, including p24, a type I membrane protein, have been
Fourier Transform Mass spectrometry (FT-ICR): 2 and multltidimensional acquisition and data processing for fast parallel acess to all MS/MS data from an MS spectrum – FT-ICR 2D
Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS) achieves high resolution and mass accuracy, allowing the identification of the raw chemical formulae of ions in complex samples. Using ion isolation and fragmentation (MS/MS), we can obtain more structural information, but MS/MS
New U(V) based molecular and supramolecular architectures. – NUMA
The importance of nuclear industry in the current energetic context necessitates an improved understanding of the speciation and redox properties of actinides both within spent nuclear fuel and in the environment. Aside from its high fundamental interest, the understanding of bonding, structure and
Low Molecular Weight Gelators as versatile supramolecular scaffolds for stem cell culture and tissue engineering – GELCELLS
The manipulation of cells to control their phenotype is a very important issue for biomedical applications such as cell therapy or tissue engineering to replace defective tissues or organ. Excluding the biochemical and genetic factors, it is known that other factors such as the micro-environment of
Photophysics of phosphorus-ligands ruthenium and iridium complexes : joint experimental and theoretical investigations – PhosphoRuIr
In order to expand the range of absorption wavelength of the dye to increase its efficiency and to lower very significantly its cost in 3rd generation solar cell devices, we chose to coordinate organophosphorus ligands, largely neglected in this field, on polypyridyl ruthenium complexes. The polypyr
Metallodrugs with antibacterial activity: from synthesis to in situ biological activity – METABACT
Objectives: to improve the antibacterial activities of molecules known to be active in vitro, and to test SOD-like complexes by grafting adjuvants to bypass the low permeability or efflux of Gram- bacteria Finality: 1) to evaluate the activity and define theantibacterial spectrum of of the compound
Parity Non-Conservation in Molecular Systems – NCPCHEM
Chirality is a hallmark of Life: With very few exceptions Nature shows a distinct preference for L-amino acids and D-sugars over their mirror images. A chiral host molecule displays typically a different response to a chiral guest molecule and its mirror image. For instance, the two chiral forms of
Understanding the properties of hierarchical zeolitic materials for a rational design of Methanol/Ethanol to Hydrocarbons (M/EtTH) catalysts – HiZeCoke
- - - 1. Frederic C. Meunier, Danny Verboekend, Jean-Pierre Gilson, Johan C. Groen, Javier Pérez-Ramírez, Influence of crystal size and probe molecule on diffusion in hierarchical ZSM-5 zeolites prepared by desilication, Microporous and Mesoporous Materials, 148(1), 2012, 115-121, DOI : 10.1016/j.mi
Thapsigargin and novel analogues: Synthesis and hemisynthesis of SERCA inhibitors with specific therapeutic profile – THASER
Thapsigargin (Tg) is a natural product that selectively inhibits (nM scale) SERCA calcium pumps in the endoplasmic reticulum, initiating a molecular cascade resulting in cell apoptosis. Therefore, unlike most cytotoxic cancer drugs, Tg is not cell cycle-dependent and can kill non dividing cancer cel
Iodine-Based Electrophilic Chiral Reagents – Design and Applications in Asymmetric Synthesis – IODINNOV
The chemistry of hypervalent iodine organic compounds, also referred to as iodanes, has experienced an impressive development since the early 1990s. Several reagents are now commercially available or readily accessible in a few synthesis steps. Used in routine by chemists as agents for oxidation rea
Theoretical investigations of the quantum dynamics of adsorbed molecules – DYQUMA
One of the aim of this project is to open new perspectives in the field of heterogeneous catalysis. We will concentrate on a microscopic approach, and give quantitative and rigorous insight for a given class of important systems. The project has effectively started 12 months ago. Results are in prog
Development of Ynamide Technologies – DYNAMITE
The development of new synthetic methods constitutes an important goal not only in organic chemistry but also in other related research domains where there is a growing demand in new molecules. The DYNAMITE project lies in this general context and deals with the development of new processes for the
Proton-triggered bistable bimetallic bioinspired systems – Bi3Pro
The main goal of this project is to understand in detail the proton-coupled electron transfer evidenced for a dinuclear mixte valent complex Fe(II)Fe(III) bearing an acidic ligand (LH). The reaction is summarized here after: Fe(III)Fe(II)–LH Fe(II)Fe(III)–L + H+. The diiron forms Fe(III)Fe(II)–LH
Redox-switchable Metallaphosphanes for Catalysis – REDOPHOS
The development of molecular structures allowing to control a given property or a chemical transformation at the molecular level via an external stimuli are timely challenges which are important, both from the fundamental and applied standpoints. In this respect, the design of ligands allowing to el
Biocatalyzed synthesis of Leishmania oligosaccharides and their use in diagnosis and therapeutic strategies (Biocatalysis - Medical applications - Carbohydrates - Leishmania) – SynBioLeish
According to the World Health Organization (WHO), over one billion people are affected by neglected tropical diseases (NTDs) and 550 000 people die each year. This considerable mortality is mainly due to a large concentration of people living in rural areas among the poorest in the world. These negl
Dynamic Polymers – Dynamic Interactive Systems for Constitutional Membranes – DYNAMERS
DYNAMERS est un projet interdisciplinaire de recherche fondamentale et appliquée qui a pour but de maîtriser les systèmes multivalents (polymères dynamiques, nanoparticules, surfaces, membranes) en utilisant une approche dynamique constitutionnelle afin de créer des dispositifs fonctionnels dont les
Bistable Molecular Nanomaterials – CROSS-NANOMAT
In the past decades, synthesis of nanoparticles has become one of the most burgeoning topics in chemistry. In a first time, this development mainly concerned syntheses of nanoparticles of metals, semiconductors and oxides. In the frame of this present proposal we will focus on coordination nanoparti
Foldzymes, Foldamers targeting Catalytic Activity – FAC
The catalytic properties of enzyme is linked to their ability to adopt well defined 3D structures. Foldamers are synthetic oligomers able to adopt well defined 3D structures. The aim of this fundamental project is to develop foldamers with catalytic activity, based on new amino acids oligomers. We
Translational study of mechanistic particularities of ferrocifenes and analogs. – MECAFERROL
Bioorganometallic chemistry of transition metals is defined as the study of organometallic complexes taking into account their specificities with the aim of solving problems of biological interest. For example, we have recently found that some organometallic complexes possessing a redox antennae ass
A Radical Approach for the Construction of Unsaturated Structures – RACUS
One of the main properties of radical reactions is the near absence of ß-elimination of oxygen groups such as alcohols, ethers, esters, carbonates or carbamates. As a consequence, radical processes have had a considerable impact in organic synthesis for the selective modification of highly oxygenate
Weak metal-metal interactions for selectivity in organometallic and coordination chemistry – Dispersion Directed Associations – WEAKINTERMET-2DA
The aim of this project was to round by various approaches the role of van der Waals forces and particularly that of London in the stabilization of transition metal complexes with unsaturated valence shell and to establish the role of the same forces in the formation of molecular aggregates of squar
Mechanisms of action and targets of new antimalarial redox molecules – MaTuRe
The emergence of resistance of Plasmodium falciparum (P. falciparum), the most virulent parasite species for humans, has been a major difficulty to treat malaria in the last four decades. These indications prompt the need for new antimalarial drugs which ideally should act with novel mechanisms of a
Bio-inspired H2-evolving mimics of NiFe Hydrogenases – NiFe-cat
In the current context of developing new technologies for a hydrogen economy, the development of new catalysts to reduce the overvoltages at the electrodes in the production devices (electrolyzers low temperature) or oxidation (fuel cells) of the hydrogen and thus generate an alternative to the use
Redox Catalysis for Sustainable Radical Synthesis – Credox
Over the last three decades, the radical chemistry has witnessed tremendous developments. Its contribution has greatly extended the repertoire of versatile processes in organic synthesis. One of the main achievements of radical chemistry is the design of polycyclization cascades that could lead to n