Dynamic Polymers – Dynamic Interactive Systems for Constitutional Membranes – DYNAMERS

Le projet a commencé effectivement le 1er janvier 2011. Nous avons démarré et accompli les principales tâches du projet concernant:
1. Synthesis of dynameric systems and their use for system preparation.
2. Dynameric membranes for gas separation and capture.
3. Nanobiostructured membranes for viruses, endotoxins and antibiotics removal
4. 3D porous reservoirs as confined multivalent dynameric platforms for quartz crystal microbalance (QCM) biosensors.

Durant les premiers 30 mois du projet, 15 publications et 4 chapitres de livre ont été publiés. D’autres publications sont soumises ou en cours de rédaction. 1 livre (Constitutional Dynamic Chemistry) et 1 numéro special Israel. J. Chem. (Constitutional Dynamic Systems) ont été publiées en collaboration par les Partenaires du Projet. Plus d’une centaine des conférences invitées ont été présentées dans le cadre du projet.

Les étapes de synthèse et de préparation des matériaux dynamères et de la mise en œuvre de systèmes (films, membranes, couches minces, etc.) ont été accomplies. Les tâches de caractérisation structurale (partenaire 1,2) et les mesures des propriétés de reconnaissance, de transport et de la mise en forme (partenaire 1, 2) sont en cours de finalisation.

1. Constitutional Dynamic Chemistry, Topics in Current Chemistry, M Barboiu Editor, Springer Verlag, 2012. ISBN 103642283438; ISBN 13 9783642283437.
2. M. Barboiu, J.M. Lehn, Constitutional Dynamic Systems, Editorial, Israel J. Chem. 2013,53(1-2), 9-10.
1. P. Kovar?íc?ek, J.-M. Lehn, , J. Am. Chem. Soc. 2012, 134, 9446-9455.
2. G. Vantomme and J.-M. Lehn, Angew. Chem. Int. Ed. 2013, 52, 3940 –3943
3. N. Hafezi and J.-M. Lehn, , J. Am. Chem. Soc. 2012, 134, 12861-12868
4. F. Dumitru, Y.-M. Legrand, E. Petit, A. van der Lee, M. Barboiu, Dalton Trans., 2012, DOI: 10.1039/c2dt31532g.
5. N. Wilhelms, S. Kulchat, and J.-M. Lehn, Helv. Chim. Acta 2012, 95, 2635-2651.
6. N. Roy, E. Buhler, J.-M.Lehn, , Polym. Chem., 2013, 4, 2949–2957.
7. G. Nasr, T. Macron, A. Gilles, E. Petit, M. Barboiu, S Chem.Commun., 2012, 48, 7398-7400. DOI: 10.1039/C2CC33603K.
8. G. Nasr , T. Macron , A. Gilles , Z. Mouline, M. Barboiu , Chem. Commun., 2012, 48, 6827-6829, DOI: 10.1039/ C2CC32656F.
9. G. Nasr, T. Macron, A.Gilles, C. Charmette, J. Sanchez, M. Barboiu,, Chem. Commun., 2012, 48(94) 11546-11548, DOI:10.1039/C2CC35821B.
10. G. Nasr, A. Gilles, T. Macron, C. Charmette, J. Sanchez, M. Barboiu, T. Israel J. Chem. 2013, 53(1-2), 97-101. DOI: 10.1002/ijch.201200081
11. L. Marin, B. Simionescu, M. Barboiu, Chem.Commun., 2012, 48, 8778-8780. DOI: 10.1039/C2CC34337A
12. L. Marin, I. Stoica, M. Mares, V. Dinu, B. C. Simionescu, M. Barboiu, J. Mat. Chem., 2013, 1 (27), 3353-3358. DOI:10.1039/c3tb20558d
13. A.Gilles, S. Mihai, G. Nasr,E. Mahon, S. Garai, A. Müller, M. Barboiu, H. Israel J. Chem. 2013, 53(1-2), 102-107.
14. S. Mihai, J. Dauthier, Y. Le Duc, A. El Mansouri, A. Mehdi, M. Barboiu, Eur. J. Inorg. Chem. 2012, 5299-5304. DOI: 10.1002/ejic.201200754
15. M. Barboiu and A. Gilles, Acc. Chem. Res., 2013, 46, doi: 10.1021/ar400025e.

DYNAMERS is an interdisciplinary fundamental and applicative research project which aims mastering multivalent adaptive systems (dynamic polymers, nanoparticles, surfaces, membranes) by using a dynamic constitutional approach to create functional devices with potential applications in areas ranging from biosensors to high selective membranes and information storage/transfer devices. Adaptive polymeric materials which are capable of responding to physical triggers or chemical effectors by modification of their very constitution represent an intriguing class of “smart” systems that are of both basic and applied interest

More generally, to broaden the scope of DYNAMERS project, our further challenges might provide new insights into the basic features that control the design of “intelligent” dynamic systems. Within this context an ultradense array of addressable nanoscopic elements that are perfectly ordered over macroscopic length scales, is emerging as the promising routes to generate adaptive templates and scaffolds for the fabrication of “fittest” materials and offers a potential solution to implementation of dynamic constitutional chemistry [1] toward functional systems such us:
a) Selective membranes for CO2 or O2/N2 separation;
b) Membranes for virus endotoxin and antibiotics capture in water;
c) Multivalent 3D surfaces for quartz crystal microbalance (QCM) biosensors
d) Dynamic nanoparticle sponges

Our project is based on the state-of-the-art of creating novel multivalent systems based of noteworthy mentioned concepts, and this can contribute enlarge the competitive position of France in this pioneering field of chemistry, materials science and nanotechnology. The key and direct objective of DYNAMERS is to provide research with a deep knowledge and expertise on Dynamic Interactive Nanosystems with environmental and biotechnological applications on the basis of a dynamic chemistry / material sciences / membrane sciences / nanosciences platform. Intersectorial research will be guided by an ambitious scientific goal of creating a new generation of highly selective multivalent nanoplatforms, which might provide new insights into the basic features controlling in real-time/space multivalent interactions between components of interest within intelligent functional systems. DYNAMERS will expose involved researchers to the process of design, generation, optimization and biomedical / biotechnological / industrial applications of a variety of functional systems like membranes, biosensors, microarrays, and nanodevices, opening the door to an emerging area paralleling those of chemistry, biology, health, and biotechnology. Moreover, the multidisciplinary nature of DYNAMERS will provide a interdisciplinary environment: chemistry, chemical biology, nanotechnology and materials, membrane and environmental sciences. The participating groups proposing this adventure are able to develop this project at the boundaries of cross scientific borders.
The scientific knowledge acquired in DYNAMERS will be important for the future optimisation of low-cost highly selective multifunctional devices (e.g. QCM biosensors, Membranes, etc.) used for industrial applications. This includes collaborations with industrial partners such as ATTANA AB (www.attana. com) and...