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Impact of the COVID19 crisis on the therapeutic management of patients treated since 2018 for newly diagnosed glioblastoma AND stage IV pancreatic cancer – IMPACT COVID19
Presentation and referral of symptomatic patients from primary into secondary care has been dramatically impacted by lockdown of the population due to the COVID-19 pandemic. That involved in particular de-prioritization of non-emergency clinical services, including diagnostics and elective specialis
Comparative analysis of anti-SARS-CoV-2 humoral and memory T cell responses in children with various degrees of immunosuppression : a case-control study – PEDIMMCO
It is currently difficult to know the proportion of children immunized during thE sars-cOv-2 epidemic. Moreover, there is still uncertainty about whether adaptive immune responses to SARS-CoV-2 are protective. Such knowledge is of immediate relevance, as it will provide insights into immunity of SAR
Social and medico-social actors facing the crisis generated by Covid-19 – CRISEsoc.JdB
During the lockdown and after the lockdown, several professionals from the social and the medico-social instituions were asked to keep logbooks which allow today to observe the effects produced by the COVID-19 crises on their professional routine and their institutional organizational models devoted
Role of the balance NET/DNase in COVID-19 severity – CORONET
Infection with COVID-19 leads to variable types of symptoms, starting with asymptomatic forms to severe acute respiratory distresses (ARDS) and death. Knowing who is at high risk to aggravate, and thus requires therapeutic intervention and closer monitoring would be very useful. We recently demonstr
Involvement of circulating fibrocytes in pathophysiology and prognosis of COVID-19 pneumonia – FIBROCO
We hypothesized that circulating fibrocytes could be a valuable biomarker during COVID-19 pneumonia. We aimed to determine the involvement of fibrocytes during COVID-19 pneumonia, and to determine if fibrocytes could be associated with prognosis. We included 57 patients in the Hospitalized group (me
Single cell and bulk T-Cell Receptor repertoire sequencing in Covid-19 – SirocCo
The quality of the adaptive immune response to COVID-19 likely determines the outcome of the disease. As with many other viral diseases, a balanced response should quickly control the infection and protect the patient, while a too strong response could lead to acute respiratory distress and other ti
Roles of type I interferons and plasmacytoid dendritic cells in Covid19 – RIPCOV
Specifically, we propose to solve the much debated role of type I interferons (IFN-I) and of plasmacytoid dendritic cells (pDCs) that are the major source of IFN-I during many viral infections. Preliminary results suggest that the response of animals to IFN-I is protective, with respect to both the
Development and characterization of electronic noses for the rapid detection of COVID-19 in exhaled breath – COVINose
Early, easy and rapid diagnosis of coronavirus disease 2019 (COVID-19) is of the utmost importance but remains challenging. Breath analysis is an innovative, non-invasive, real-time, point-of-care technique for detecting volatile organic compounds (VOCs) in expired breath with potential for use in d
Modulation of SARS-CoV-2 cell entry – COVENTRY
There is indeed an urgent need to develop treatments for COVID-19. COVID-19 pandemic is due to the SARS-CoV-2 coronavirus that infects human cells through binding of its spike S protein to cell receptors including the ACE2 protein. The entry of virus into the cell after binding to its receptor is st
Seasonal detection of Sarbecoviruses in bats from North Vietnam – SO-VIET-BAT
Ten months after the first reported cases of Covid-19 in Wuhan, the origin of the SARS-CoV-2 virus still continues to be debated. In order to avoid other epidemics in the future, it appears crucial to identify the different steps that led to the first human contamination by an animal, in particular