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In order to develop rational strategies for the development of inhibitors of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) it is essential to understand the molecular basis of different aspects of the viral cycle. Coronaviruses are enveloped positive-sense single strand RNA viruses th

The SARS-CoV-2 identified in China in January 2020 is the cause of an unprecedented pandemic. Although mostly asymptomatic, in 20% of cases CoViD-19 will lead to severe forms, characterized by a cytokine storm, major pulmonary inflammation, degradation of alveolar epithelial cells and capillary endo

SARS-CoV-2 infection is characterized by a range of symptoms including fever, cough, fatigue and myalgia in the majority of cases. More severe cases of COVID-19 show development of acute respiratory distress syndrome (ARDS) leading to mortality. A high number of patients with ARDS secondary to COVID

Large-scale epidemiological studies have given first indications that smokers are to some extent "protected" against COVID-19. Here, we want to pursue our hypothesis that the nicotinic acetylcholine receptor (nAChR) is part of the infection process and the pathology in the lung, especially with res

COVID-19 cardiac, vascular and renal impacts are frequent and massive in severe forms of the disease. Our project addresses the cellular and molecular basis of water and electrolytes balance alterations by describing the fates and functions of cardiovascular and renal cells during the course of the

Among other consequences, the Covid-19 crisis has prompted the public authorities to rethink the use of public space, particularly roads, in order to develop means of transport that are both efficient and adapted to the health context. Fearing a desertion of public transport and a massive shift towa

The end of the containment allowed social and professional activities resumption while raising questions about the risk of SARS-CoV-2 spreading and protective measures to involve. Conversations (normal speech) or professional interactions (loud speech) have been identified as an increased risk of S

Nucleoside analogues inhibitors (NAI) play a key role in every approved antiviral therapy in use so far. The situation is unlikely to change drastically in the fight against the SARS-CoV-2 responsible for the COVID-19 pandemic: The NAI Remdesivir is the only approved drug in use so far, but require

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARScov2) is a new coronavirus discovered in December 2019 in Wuhan, China and currently responsible of a worldwide outbreak and the death of more than 25,000 patients in France. The more severe form of COVID-19 disease induces a pneumonia with pr

The Covid-19 pandemic has triggered a global health crisis with significant disruptions to healthcare, financial and economic systems. The project COVIDOR focuses on the resilience of organizations that better resisted to Covid-19 lockdown measures in order to draw lessons to cope with future extrem

The beginning of 2020 has seen the emergence of COVID-19 pandemic, a respiratory disease caused by a novel coronavirus (CoV), the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In the absence of efficient cure or vaccine currently available, there is an imminent need to better underst

Coronavirus disease 2019 (COVID-19), which is caused by the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become pandemic, in the absence of an approved drug treatment or prophylactic vaccine. The virus surface spike protein (S), which mediates coronavirus ent