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Immunotherapy has proven to be a game changer in the treatment of cancer. The most emblematic clinical successes of cancer immunotherapy can arguably be attributed to the inhibition of the PD-1/PD-L1 axis using blocking antibodies referred to as immune checkpoint inhibitors (ICI). These drugs may re

The objective of the VacMuc-IL-7 project is to explore how IL-7 interacts with mucosal immune system in both the lungs and the vagina and to study its potential as a mucosal vaccine adjuvant. IL-7 and the antigens will be administered locally, alone or adsorbed onto biodegradable poly-lactic acid n

In 2019, tuberculosis (TB) remains a global public health emergency as it is the deadliest infective disease above HIV. Moreover, despite increasing attention from the World Health Organization in the last decades, the global incidence only drops by 2% each year. On the opposite, the proportion of m

The preclinical development of cationic antimicrobial peptides as an alternative to antibiotics is precluded, among other processes, by their inactivation by salts. Taking inspiration from marine biodiversity, our goal is to turn salt-sensitive human defensins into salt-stable defensins. This ambiti

We work with chemists to produce analogs of CORM-401 conjugated with another molecule that may target CO to the adipose tissue. This idea was inspired by a publication that used a similar strategy to enhance the accumulation of anti-inflammatory drugs in this tissue. CO released by CORM-401 is known

In the field of cardio-vascular diseases, the last decade was marked by the development of percutaneous endocardiac and endovascular therapeutic solutions, leading to less invasive and cost effective strategies such as arrhythmia catheter ablation, transcatheter aortic valve implantation, mitral val

While acute inflammation is a short-term adaptive response to harmful stimuli, chronic inflammation is prolonged, dysregulated and deleterious, and is implicated in the pathogenesis of many diseases including asthma, arthritis, and cancer, as well as in neurodegenerative and cardiovascular diseases.

Ferrocifens have been demonstrated to display anticancer properties by an original mechanism dependent on redox properties and generation of active metabolites targeting mitochondrial enzymes. However, these molecules are highly insoluble in water, requiring a formulation stage before they can be in

Triple Negative Breast Cancers (TNBC) represent an urgent unmet medical need with a median of relapse-free survival of 2.6 years and a risk of death of almost 100% at relapse. Immunotherapy (IT) approaches are under active investigation in TNBC, including in Centre Léon Bérard. While multiple eviden

Glioblastoma (GBM), the most aggressive form of glial tumors (overall survival 2-3 years), represent more than 50% of brain cancer. In the standard of care of treatment, the main option is the surgical resection but because of the infiltrating property of GBM and the difficulty to differentiate heal

Bacterial pneumonia is a leading cause of morbidity/mortality worldwide. Antibiotics constitute the standard of care but face with the emergence of antimicrobial resistance (AMR) and the curative failure. The project aims at assessing an adjunct to antibiotic therapy as an emerging concept of overco

The WHO has designated Respiratory Syncytial Virus (hRSV) and metapneumovirus (hMPV), as a high priority targets for vaccine development, yet no approved vaccines is presently available against these viruses. Several vaccine strategy are currently under development with 19 on going clinical trials.

This project aims to design a new generation of pharmacological inhibitors capable of countering the consequences of an ischemic episode. They target a protein that we have recently identified and implicated in the resistance of organs to ischemia. The clinical application is kidney transplantation.

Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis, is a complex disease that results from a combination of genetic and environmental factors, with a key role for the gut microbiota. It is characterised by chronic inflammation associated with an imbalance in

The lasSoCocci project employs a multidisciplinary approach combining microbiology, biochemistry, chemistry and molecular biology to achieve the following objectives: 1) To understand the molecular mechanisms of the peptides effects on virulence and antibiotic resistance. These studies are first pe

Biotherapeutics play a critical role in the treatment of human diseases and their market is expanding rapidly. Most biotherapeutics are expressed as recombinant glycoproteins where glycosylation controls properties such as immunogenicity, stability and bioactivity. Thus, glycosylation can directly a

They are numerous studies concerning the topical delivery of antiparasitic drug for the treatment of cutaneous leishmaniasis. However, these formulations are not always effective, are expensive and complex or use aqueous solvents, that can be detrimental to stability in particular. So there is a nee

The bacterial resistance to antibiotics is a crucial issue in many countries. Urgent innovative solutions are needed to fight infections caused by nosocomial Gram-negative bacilli, such as P. aeruginosa, A. baumannii, etc. Alternatives strategies to antibiotherapy are expected to broaden the therape

We propose a pioneering approach that has never been addressed to date and will go well beyond the current state-of-the-art strategies for sublingual vaccination: association of a mucoadhesive delivery system with a particulate antigen formulation containing an immunostimulant. Such new technology i

Large production of stem cell-derived retinal cells is not available – we wish to produce high quantity of photoreceptors (PRs) from a storable multipotent retinal progenitor cells (RPCs) High enriched adherent culture of PRs derived from human iPSC is actually not described – we wish to establish

Low back pain (LBP), affecting over 80% of adults during their lifetime and resulting in considerable disability and socioeconomic consequences, is often associated with intervertebral disc (IVD) degeneration. The IVD consists of a gel-like nucleus pulposus (NP) surrounded by a densely fibrous annul

The main objective of the multidisciplinary TEPEE project concerns the design of “hybrid” systems that combine the most advanced and promising developments in nanomedicine and cell therapy. As such, custom-made functional polymersomes (polymer vesicles/microcapsules) will be covalently conjugated to

Respiratory syncytial virus (RSV) is the main agent responsible for bronchiolitis, and a major cause of hospitalization and viral death in infants worldwide. No vaccine has been obtained so far. Only two antiviral products are available, but are only administered in extreme cases due to their poor b

Malaria, caused by Plasmodium species, particularly falciparum and vivax, is the most important human parasitic disease and the constant selection and spreading of multi-resistant parasites, including to the artemisinin-based combination therapies for falciparum, seriously threaten malaria treatment

CONTEXT: T lymphocytes are critical cellular actors in the host response to various pathogens i.e. viruses, bacteria and fungi and in the control of malignant cell transformation. Importantly, the thymus ensures a continuous production of naïve T cells with a diverse TCR repertoire capable to mount

Neuropathic pain refers to pains that arise as direct consequence of a lesion or disease affecting the somatosensory nervous system. It affects 5-10 % of the general population and represents heavy burden costs for the health insurance systems and the society. Clinically, neuropathic pains are chara

Neurofibromatosis Type 1 (NF1) is a monogenetic disease affecting around 1 in 3000 live births. Affected patients present a diverse spectrum of symptoms, and nearly all individuals with NF1 develop benign but irritating, bleeding and often painful tumors called cutaneous neurofibromas located at ner

Amyotrophic Lateral Sclerosis (ALS) is an incurable disorder, characterized by degeneration of motor neurons (MN) leading to progressive paralysis and death usually within 3 to 5 years after diagnosis. ALS is a rare disorder, however, a recent epidemiological study predicts that, along with aging of

Retinitis pigmentosa (RP) and age-related macular degeneration (AMD) affect millions of people worldwide and may ultimately lead to blindness. In AMD and in some forms of RP, the primary death or dysfunction of the retinal pigment epithelium (RPE) induces the secondary death of photoreceptors (PRs).

In this project, we aim to develop unique platforms combining human brain organoids and microfluidic organ-on-chip technologies to study angiogenesis in the context of brain vasculature and brain tumor evolution. This approach will allow us i) to directly observe and quantify the fundamental mechani

According to the World Health Organization, «antibiotic resistance is one of the most serious threats to global health, food security and development.« The last decades have been marked by the emergence of multidrug resistant bacteria to such an extent that antibiotics which until now were commonly

What determines the intensity and length of the CD4 T cell response is incompletely known. As MHC-II peptide complexes persist several weeks in vivo, disappearance of antigen (Ag) does not explain the prototypic contraction phase observed at day 6-8 of any primary responses. We previously showed tha

The objective of this project mixing organic chemistry and virology is to develop Adeno-Associated Vectors (AAVs) chemically modified to improve its safety and efficacy. AAVs are now becoming therapeutic products, however, clinical trials showed critical limitations: high doses are required to achie

This project proposes the development of molecular photosensitizers more selective in order to target retinal neovascularisations within the scope of the treatment of age related macular degeneration (AMD) and diabetic retinopathy. This enhanced selectivity will arise from two elements. First, th

Since the introduction of penicillin, numerous antibiotic drugs emerged, drastically reducing the mortality due to bacterial infections. At the beginning of the seventies, the number of newly marketed drugs began to decrease while bacterial resistance to antibiotics is recorded to be continuously ri