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Nowadays, natural product research is still largely based on random screening of microbial extracts. This strategy is costly and time consuming and is one reason of the current decrease and mutation of natural product research in pharmaceutical companies. This is even amplified in the case of microb

Harvesting involves removing low-concentration, undamaged cells from their culture medium at minimal cost. It is estimated that this crucial step accounts for a third of the total cost of microalgal biomass production in industrial processes. In this context, flotation is an interesting separation t

Improving the performance of microbial platforms to transform biomass into bioproducts is crucial for the development of sustainable and economically relevant biotechnological processes. Metabolic engineering to optimize expression of native or heterologous pathways often leads to significant energy

Many authors have drawn attention to the risk of a shortage in the production of phosphate fertilizers due to a foreseeable depletion of the P mineral deposits. The problem is global, but is even more significant for Europe, which has very few P deposits, making its agriculture very dependent on imp

BioBrickEvolver aims at developing such a continuous system for directed evolution in the gram-positive bacterium Bacillus subtilis. An important step towards biotechnological applications will also be made by using the proposed system for: the evolution of new transcription factors for genetic circ

While anaerobic digestion has regained a lot of interest with intensive industrial development in the field of waste treatment, fermentation processes represent a great potential way of innovation, particularly for the production of hydrogen, as emerging energy carrier. The main objective of the Pro

GRaFTiNG is tackling a timely topic related to the development of novel and fully bio-sourced polymers. The objective is to explore a two-step enzymatic cascade leading to tailor-made polyelectrolytes using a sustainable and environmentally friendly approach. Structures with different substituents a

In this process, hemicelluloses will be depolymerized into sugars over an acidic catalyst. The sugars obtained in a first reactor compartment will be transferred to a second compartment by membrane separation and then hydrogenated to polyols over a metal catalyst. Results are confidential until thei

Thanks to their fast growth and their high lipids content, micro-algae are considered as potentially-excellent candidates to provide third generation biofuels in the future. Nevertheless, some knowledge gaps still need to be tackled. In the downstream of the value chain, the challenge is to reach te

Growing concerns over fossil reserve limitations and greenhouse gas effects have focused attention on the need to develop sustainable biofuels. While most industrial developments have focused on the production of ethanol (bioethanol) or oil (converted to biodiesel), microbial production of medium-ch

Lignocellulosic biomass (LCB) is a renewable and inexhaustible carbon source on Earth and its valorization will drive sustainable bioeconomy. Microorganisms produce a huge repertoire of carbohydrate active enzymes in order to utilize LCB as carbon source. Bacteroides, encode fine-tuned gene clusters

Brown algae are the dominant primary producers in temperate and polar coastal ecosystems. These photosynthetic eukaryotes thus represent a huge marine biomass which is mostly constituted by complex polysaccharides differing from plant polysaccharides. The three main categories of polysaccharides are

Microalgae are interesting renewable energy source with attractive industrial properties. To be aware of the production progress, several approaches can be applied to measure their production. Nevertheless, the current analyzes are limited to a monoparametric approach that often destroys the cells a